Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | TYMP | P19971 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11738105 | 0.77 | ERCC1 (0.38) | FGFR1HTTMAPK1MEN1ALOX15 | |
| SCHEMBL4653135 | 0.72 | ALDH1A1 (0.36) | FGFR1MEN1KMT2ARAB9AKDM4E | |
| SCHEMBL7564095 | 0.71 | CYP3A4 (0.47) | FGFR1ALDH1A1GAACYP1A2 | |
| SCHEMBL9471238 | 0.69 | TSHR (0.46) | FGFR1HTTKMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL5753871 | 0.68 | LMNA (0.36) | MAPK1MEN1KMT2AALOX5RAB9A | |
| SCHEMBL12349896 | 0.67 | LMNA (0.58) | MAPK1MEN1KMT2ARAB9AKDM4E | |
| SCHEMBL4219701 | 0.66 | ALDH1A1 (0.53) | FGFR1MEN1ALOX15KMT2AALOX5 | |
| SCHEMBL141173 | 0.66 | POLB (0.41) | FGFR1HTTMEN1KMT2ARAB9A | |
| SCHEMBL12270200 | 0.66 | KDM4E (0.32) | MEN1ALOX15KMT2AKDM4EALDH1A1 | |
| SCHEMBL25457541 | 0.65 | MEN1 (0.35) | MEN1KMT2ASMN1; SMN2GAACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107709332-B | C, O-spiro aryl glycoside compound and preparation and application thereof | 中国科学院上海药物研究所 | 2019-12-20 | — | — | CN | disclosed |
| CN-107709332-A | A kind of C, O loop coil aryl glycoside class compound and its preparation and application | 中国科学院上海药物研究所 | 2018-02-16 | — | — | CN | disclosed |