Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GPX4 | P36969 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28226342 | 0.72 | LMNA (0.51) | LMNAKDM4EMAPTALDH1A1GAA | |
| SCHEMBL29629574 | 0.71 | PIM1 (0.41) | LMNAKDM4ECES2CES1MAPT | |
| SCHEMBL13506760 | 0.71 | ATM (0.46) | LMNAMAP3K14KDM4EMAPTPOLB | |
| SCHEMBL28201270 | 0.68 | FGFR1 (0.36) | KDM4EALDH1A1GAAALOX5MEN1 | |
| SCHEMBL28057093 | 0.68 | RECQL (0.43) | LMNAMAP3K14KDM4EPOLBALDH1A1 | |
| SCHEMBL9471238 | 0.67 | TSHR (0.46) | LMNAKDM4EMAPTPOLBALDH1A1 | |
| SCHEMBL20376354 | 0.67 | PTGS2 (0.44) | LMNAMAP3K14KDM4EGPX4 | |
| SCHEMBL11738105 | 0.67 | ERCC1 (0.38) | LMNAMAPTALDH1A1GAAHPGD | |
| SCHEMBL4653135 | 0.66 | ALDH1A1 (0.36) | KDM4EMAPTPOLBALDH1A1GAA | |
| SCHEMBL27944252 | 0.66 | POLB (0.47) | LMNAMAP3K14MAPTPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670804-A2 | HETEROBICYCLIC COMPOUNDS AS PHARMACEUTICALLY ACTIVE AGENTS | GPC Biotech AG (DE) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005023818-A2 | HETEROBICYCLIC COMPOUNDS AS PHARMACEUTICALLY ACTIVE AGENTS | GPC BIOTECH AG (DE) | 2005-03-17 | — | — | WO | disclosed |