Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | TYK2 | P29597 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28058293 | 0.71 | HPGDS (0.35) | IKBKBROCK2JAK1TYK2JAK3 | |
| SCHEMBL28202148 | 0.71 | GSK3A (0.42) | ROCK2CDK2 | |
| SCHEMBL28202187 | 0.71 | F10 (0.34) | ROCK1CDK2 | |
| SCHEMBL28202753 | 0.70 | DYRK1A (0.40) | CDK2 | |
| SCHEMBL28202190 | 0.69 | ERN1 (0.35) | — | |
| SCHEMBL28202183 | 0.68 | ERN1 (0.36) | — | |
| SCHEMBL28202145 | 0.65 | F2RL3 (0.34) | — | |
| SCHEMBL27918809 | 0.64 | ALDH1A1 (0.44) | — | |
| SCHEMBL28170955 | 0.63 | NPC1 (0.41) | — | |
| SCHEMBL24628752 | 0.60 | ALDH1A1 (0.46) | CCNE2CDK4CCND1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105473568-B | 1, 7-naphthyridine derivatives | 豪夫迈·罗氏有限公司 | 2018-02-13 | — | — | CN | disclosed |