Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 7/20 | 1.00 |
| ▸ | TDP2 | O95551 | 3/20 | 0.69 |
| ▸ | AHR | P35869 | 2/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.61 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.61 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.60 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.60 |
| ▸ | CACNG8 | Q8WXS5 | 3/20 | 0.60 |
| ▸ | CMA1 | P23946 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.50 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3519711 | 1.00 | PGR (1.00) | PGRTDP2AHRCYP1A2CYP11B1 | |
| SCHEMBL10711869 | 0.88 | PGR (0.78) | PGRTDP2AHRCMA1 | |
| SCHEMBL1900155 | 0.87 | AHR (0.77) | PGRTDP2AHRCYP1A2CYP11B1 | |
| SCHEMBL3132725 | 0.85 | PGR (0.73) | PGRTDP2AHRCYP1A2CYP11B1 | |
| SCHEMBL18010817 | 0.82 | TDP2 (1.00) | PGRTDP2PARP10PARP11 | |
| SCHEMBL154614 | 0.81 | AHR (1.00) | PGRTDP2AHRCYP1A2CYP11B1 | |
| SCHEMBL1900363 | 0.81 | PGR (0.68) | PGRTDP2AHRCYP1A2CYP11B1 | |
| SCHEMBL8263674 | 0.81 | PGR (0.68) | PGRTDP2AHRCYP1A2CYP11B1 | |
| SCHEMBL18189570 | 0.81 | GRIA1 (0.73) | PGRTDP2AHRCYP1A2CYP11B1 | |
| SCHEMBL10714806 | 0.81 | TDP2 (0.69) | PGRTDP2AHRCYP1A2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107750250-A | Indolone compounds and their use as ampa receptor modulators | 詹森药业有限公司 | 2018-03-02 | — | — | CN | claimed |
| CN-107750250-A | Indolone compounds and their use as ampa receptor modulators | 詹森药业有限公司 | 2018-03-02 | — | — | CN | disclosed |