Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 5/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.61 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.61 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.60 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.60 |
| ▸ | CACNG8 | Q8WXS5 | 3/20 | 0.60 |
| ▸ | AHR | P35869 | 2/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.50 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.50 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
| ▸ | TDP2 | O95551 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1897593 | 0.87 | PDE3B (0.68) | PGRCYP1A2CYP11B1CYP11B2PDE3B | |
| SCHEMBL3309677 | 0.86 | KIF11 (0.62) | PGRCYP1A2CYP11B1CYP11B2PDE3B | |
| SCHEMBL3132725 | 0.85 | PGR (0.73) | PGRCYP1A2CYP11B1CYP11B2PDE3B | |
| SCHEMBL18189405 | 0.83 | GRIA1 (0.70) | PGRCYP1A2CYP11B1CYP11B2PDE3B | |
| SCHEMBL152963 | 0.81 | AHR (0.61) | PGRCYP1A2CYP11B1CYP11B2PDE3B | |
| SCHEMBL3519711 | 0.81 | PGR (1.00) | PGRCYP1A2CYP11B1CYP11B2PDE3B | |
| SCHEMBL8263674 | 0.81 | PGR (0.68) | PGRCYP1A2CYP11B1CYP11B2PDE3B | |
| SCHEMBL28203333 | 0.81 | PGR (1.00) | PGRCYP1A2CYP11B1CYP11B2PDE3B | |
| SCHEMBL10714806 | 0.81 | TDP2 (0.69) | PGRCYP1A2CYP11B1CYP11B2PDE3B | |
| SCHEMBL1900635 | 0.81 | PDE3B (0.64) | PGRCYP1A2CYP11B1CYP11B2PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011056985-A2 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2011-05-12 | — | — | WO | disclosed |