Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 3/20 | 0.80 |
| ▸ | CES2 | O00748 | 2/20 | 0.80 |
| ▸ | FNTA | P49354 | 2/20 | 0.64 |
| ▸ | FNTB | P49356 | 2/20 | 0.64 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.64 |
| ▸ | F2 | P00734 | 2/20 | 0.57 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.56 |
| ▸ | PLG | P00747 | 1/20 | 0.55 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.55 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.55 |
| ▸ | C1S | P09871 | 1/20 | 0.55 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylpyruvate SCHEMBL43235 | 1.00 | CES1 (0.80) | CES1CES2FNTAFNTBAKR1B1 | |
| Phenylpyruvate SCHEMBL28233246 | 0.97 | CES1 (0.76) | CES1CES2FNTAFNTBAKR1B1 | |
| Phenylpyruvate SCHEMBL28233232 | 0.97 | CES1 (0.76) | CES1CES2FNTAFNTBAKR1B1 | |
| Phenylpyruvate SCHEMBL27281240 | 0.97 | CES1 (0.76) | CES1CES2FNTAFNTBAKR1B1 | |
| Phenylpyruvate SCHEMBL468389 | 0.97 | CES1 (0.76) | CES1CES2FNTAFNTBAKR1B1 | |
| Phenylpyruvate SCHEMBL3408866 | 0.97 | CES1 (0.76) | CES1CES2FNTAFNTBAKR1B1 | |
| Phenylpyruvate SCHEMBL11193388 | 0.97 | CES1 (0.76) | CES1CES2FNTAFNTBAKR1B1 | |
| Phenylpyruvate SCHEMBL28232350 | 0.97 | CES1 (0.76) | CES1CES2FNTAFNTBAKR1B1 | |
| Phenylpyruvate SCHEMBL9217988 | 0.97 | CES1 (0.76) | CES1CES2FNTAFNTBAKR1B1 | |
| Phenylpyruvate SCHEMBL6850951 | 0.97 | CES1 (0.76) | CES1CES2FNTAFNTBAKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109652391-A | A kind of L-phenylalanine TRANSAMINASE POLYPEPTIDES and its application | 中国科学院华南植物园 | 2019-04-19 | — | — | CN | disclosed |
| CN-108685915-A | Jamaicin or its active metabolite are preparing the application in preventing and/or treating phenylketonuria disease drug | 中国医学科学院药物研究所 | 2018-10-23 | — | — | CN | disclosed |
| CN-105503768-B | The preparation method of the fluorescence of alpha ketoglutaric acids/ultraviolet molecular probe and its application in biological specimen | 曲阜师范大学 | 2018-01-30 | — | — | CN | disclosed |