SCHEMBL28204512

SCHEMBL28204512

C=Cc1ccc2c(c1SC1CCCCC1)C(=O)NC2=O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.53
MAOB P27338 1/20 0.53
ALDH1A1 P00352 4/20 0.39
MAPT P10636 3/20 0.39
PKM P14618 3/20 0.39
KDM4E B2RXH2 2/20 0.39
MEN1 O00255 2/20 0.39
POLB P06746 2/20 0.39
KMT2A Q03164 2/20 0.39
MAPK1 P28482 1/20 0.39
NTSR1 P30989 1/20 0.39
RECQL P46063 1/20 0.39
CACNA1B Q00975 1/20 0.39
APBA1 Q02410 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
CTDSP1 Q9GZU7 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
PARP1 P09874 2/20 0.35
HPGD P15428 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL110590 0.72 MAOA (0.57) MAOAMAOBALDH1A1MAPTPKM
SCHEMBL31085461 0.72 MAOA (0.57) MAOAMAOBALDH1A1MAPTPKM
SCHEMBL523108 0.70 MAOA (1.00) MAOAMAOBALDH1A1MAPTPKM
Zinc Ion SCHEMBL8672070 0.70 MAOA (0.55) MAOAMAOBALDH1A1MAPTPKM
SCHEMBL28735100 0.69 PARP1 (0.40) MAOAMAOBALDH1A1KDM4ETDP1
SCHEMBL626418 0.64 GSK3B (0.46) ALDH1A1MAPTKDM4EMEN1POLB
SCHEMBL10824282 0.63 PPOX (0.36) MAOAMAOBALDH1A1KDM4EPARP1
Iodide SCHEMBL2495412 0.62 GSK3B (0.45) ALDH1A1MAPTKDM4EMEN1POLB
Phthalimide SCHEMBL8689113 0.62 MAOA (0.57) MAOAMAOBALDH1A1MAPTPKM
SCHEMBL8500125 0.61 MAOA (0.48) MAOAMAOBALDH1A1MAPTPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107841008-A Easily-processed reinforced styrene butadiene rubber and preparation method thereof 中国石油天然气股份有限公司 2018-03-27 CN claimed
CN-107841005-A Easily-processed reinforced nitrile rubber and preparation method thereof 中国石油天然气股份有限公司 2018-03-27 CN claimed