Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 3/20 | 0.68 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.68 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.56 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21579366 | 0.89 | LOXL2 (0.70) | CYP4F2CYP4A11LOXL2HIF1ASLC7A5 | |
| SCHEMBL16355834 | 0.86 | SLC7A5 (0.57) | CYP4F2CYP4A11LOXL2HIF1ASLC7A5 | |
| SCHEMBL21089603 | 0.85 | HIF1A (0.61) | CYP4F2CYP4A11LOXL2HIF1ASLC7A5 | |
| SCHEMBL308038 | 0.84 | LOXL2 (0.64) | CYP4F2CYP4A11LOXL2HIF1ASLC7A5 | |
| SCHEMBL14143797 | 0.84 | LOXL2 (0.64) | CYP4F2CYP4A11LOXL2HIF1ASLC7A5 | |
| SCHEMBL14793785 | 0.83 | MEP1B (0.63) | HIF1AFOLH1MRGPRX4PDCD1CD274 | |
| SCHEMBL11846611 | 0.82 | CYP4F2 (0.64) | CYP4F2CYP4A11LOXL2HIF1ASLC7A5 | |
| Hydrochloric Acid SCHEMBL11854001 | 0.81 | CYP4F2 (0.62) | CYP4F2CYP4A11LOXL2HIF1ASLC7A5 | |
| SCHEMBL45633 | 0.81 | LOXL2 (0.68) | CYP4F2CYP4A11LOXL2HIF1ASLC7A5 | |
| SCHEMBL28206352 | 0.81 | CYP4A11 (0.60) | CYP4F2CYP4A11LOXL2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107873023-A | 3-alkyl-4-amido-bicyclo [4, 5, 0] hydroxamic acids as HDAC inhibitors | 福马治疗股份有限公司 | 2018-04-03 | — | — | CN | disclosed |