Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | RARA | P10276 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27843061 | 0.84 | SRD5A1 (0.38) | ALDH1A1NPC1TP53TSHRRAB9A | |
| SCHEMBL27814942 | 0.83 | ALDH1A1 (0.43) | ALDH1A1TTRMAPTNPSR1LMNA | |
| SCHEMBL28016450 | 0.81 | KMO (0.45) | ALDH1A1HPGDTTRNPC1TP53 | |
| SCHEMBL28093247 | 0.77 | SRD5A1 (0.36) | HPGDNPC1MAPTTSHRRAB9A | |
| SCHEMBL28185749 | 0.75 | RXRA (0.35) | SRD5A1SRD5A2 | |
| SCHEMBL28853255 | 0.73 | TSHR (0.36) | ALDH1A1HPGDTSHRLMNASRD5A1 | |
| SCHEMBL27632090 | 0.73 | CA1 (0.39) | ALDH1A1HPGDNPC1MAPTRAB9A | |
| SCHEMBL28856733 | 0.71 | KMT2A (0.39) | ALDH1A1NPC1MAPTRAB9ANPSR1 | |
| SCHEMBL27775494 | 0.70 | RARB (0.31) | RARBRARG | |
| SCHEMBL28046652 | 0.70 | CA1 (0.36) | TTRNPC1RAB9ARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104910161-B | Pyrazolopyrimidine compound and method as JAK inhibitor | 健泰科生物技术公司 | 2018-03-30 | — | — | CN | disclosed |