Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFB | P00751 | 6/20 | 0.60 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 4/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16401682 | 0.78 | ROCK2 (0.49) | CFBROCK2CA2CA1CA9 | |
| SCHEMBL16400733 | 0.76 | CFB (1.00) | CFB | |
| SCHEMBL17782219 | 0.74 | NR1H2 (0.51) | CFBROCK2CA2CA1CA9 | |
| SCHEMBL3025313 | 0.74 | DRD2 (0.60) | CFBDRD2DRD3LMNA | |
| SCHEMBL3643723 | 0.74 | DRD2 (0.60) | CFBDRD2DRD3LMNA | |
| SCHEMBL29997756 | 0.74 | DRD2 (0.60) | CFBDRD2DRD3LMNA | |
| SCHEMBL28168588 | 0.74 | DRD2 (0.48) | CFBDRD2DRD3ROCK2KMT2A | |
| SCHEMBL20012108 | 0.74 | CFB (0.69) | CFBDRD2DRD3 | |
| SCHEMBL28065011 | 0.74 | CFB (0.44) | CFBDRD2DRD3ROCK2CA2 | |
| SCHEMBL16401372 | 0.73 | TMEM97 (0.48) | CFBDRD2ROCK2CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105579444-B | Piperidinylindole derivatives and their use as complement factor B inhibitors | 诺华股份有限公司 | 2018-05-01 | — | — | CN | disclosed |