Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 7/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | CFB | P00751 | 1/20 | 0.44 |
| ▸ | CPT2 | P23786 | 1/20 | 0.41 |
| ▸ | CPT1A | P50416 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | CA7 | P43166 | 2/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22721972 | 0.83 | TMEM97 (0.56) | TMEM97SIGMAR1PARP14PARP10 | |
| SCHEMBL29540420 | 0.83 | TMEM97 (0.56) | TMEM97SIGMAR1PARP14PARP10 | |
| SCHEMBL17782219 | 0.82 | NR1H2 (0.51) | ROCK2CFBCPT2CPT1ACA12 | |
| SCHEMBL16401682 | 0.79 | ROCK2 (0.49) | TMEM97SIGMAR1ROCK2CFBCPT2 | |
| SCHEMBL12478146 | 0.79 | TMEM97 (0.49) | TMEM97SIGMAR1KMT2ALMNATP53 | |
| SCHEMBL30611182 | 0.77 | LMNA (0.57) | KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL3378097 | 0.76 | TMEM97 (0.51) | TMEM97SIGMAR1CFBKMT2ATP53 | |
| SCHEMBL31421713 | 0.75 | LMNA (0.47) | TMEM97SIGMAR1KMT2ALMNAALDH1A1 | |
| SCHEMBL28210587 | 0.73 | CFB (0.60) | ROCK2CFBCPT2CPT1AKMT2A | |
| SCHEMBL8303313 | 0.72 | TMEM97 (0.58) | TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022192-A1 | PIPERIDINYL INDOLE DERIVATIVES AND THEIR USE AS COMPLEMENT FACTOR B INHIBITORS | Novartis AG (CH) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015009616-A1 | PIPERIDINYL INDOLE DERIVATIVES AND THEIR USE AS COMPLEMENT FACTOR B INHIBITORS | NOVARTIS AG (CH) | 2015-01-22 | — | — | WO | disclosed |