Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2521569 | 0.88 | KMT2A (0.46) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL231935 | 0.84 | VCAM1 (0.56) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL1984721 | 0.82 | KMT2A (0.51) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL4387858 | 0.82 | KMT2A (0.51) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL7226710 | 0.81 | KMT2A (0.60) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL23117030 | 0.81 | KMT2A (0.50) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL29768558 | 0.81 | KMT2A (0.50) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL10240181 | 0.81 | KMT2A (0.50) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL29719600 | 0.81 | KMT2A (0.50) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL967857 | 0.81 | VCAM1 (0.52) | KMT2AMEN1CA1CA2MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106588925-B | It is a kind of to prepare the luxuriant method of the pyridine ring of 1,4,7,10 4 azepine 2,6 | 天津羲泽润科技有限公司 | 2018-03-30 | — | — | CN | disclosed |
| CN-106588925-A | Method for preparing 1,4,7,10-tetraaza-2,6-pyridinophane | 天津羲泽润科技有限公司 | 2017-04-26 | — | — | CN | disclosed |
| EP-1740578-B1 | 4- 2- (CYCLOALKYLAMINO) PYRIMIDIN-4-YL ] - (PHENYL) - IMIDAZOLIN-2- ONE DERIVATIVES AS P38 MAP- KINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | MITSUBISHI TANABE PHARMA CORP (JP) | 2010-12-15 | — | — | EP | disclosed |
| US-7700771-B2 | Heterocyclic compound which may be used as a medicine having p38 MAP kinase inhibitory activity | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-04-20 | — | — | US | disclosed |
| US-7423154-B2 | Asymmetric process for the preparation of diarylethylpiperazines derivatives and novel asymmetric diarylmethylamines as intermediates | ASTRAZENECA AB (SE) | 2008-09-09 | — | — | US | disclosed |
| US-7423154-B2 | Asymmetric process for the preparation of diarylethylpiperazines derivatives and novel asymmetric diarylmethylamines as intermediates | ASTRAZENECA AB (SE) | 2008-09-09 | — | — | US | disclosed |
| US-7423154-B2 | Asymmetric process for the preparation of diarylethylpiperazines derivatives and novel asymmetric diarylmethylamines as intermediates | ASTRAZENECA AB (SE) | 2008-09-09 | — | — | US | disclosed |
| EP-1368325-B1 | NEW ASYMMETRIC PROCESS FOR THE PREPARATION OF DIARYLMETHYLPIPERAZINES DERIVATIVES AND NOVEL ASYMMETRIC DIARYLMETYLAMINES AS INTERMEDIATES | ASTRAZENECA AB (SE) | 2008-08-27 | — | — | EP | disclosed |
| EP-1368325-B1 | NEW ASYMMETRIC PROCESS FOR THE PREPARATION OF DIARYLMETHYLPIPERAZINES DERIVATIVES AND NOVEL ASYMMETRIC DIARYLMETYLAMINES AS INTERMEDIATES | ASTRAZENECA AB (SE) | 2008-08-27 | — | — | EP | disclosed |
| US-7384952-B2 | Pyrazolopyrimidine compound and a process for preparing the same | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2008-06-10 | — | — | US | disclosed |
| EP-1740578-A1 | 4- 2- (CYCLOALKYLAMINO) PYRIMIDIN-4-YL ] - (PHENYL) - IMIDAZOLIN-2- ONE DERIVATIVES AS P38 MAP- KINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | TANABE SEIYAKU CO., LTD. (JP) | 2007-01-10 | — | — | EP | disclosed |
| US-20060135525-A1 | Pyrazolopyrimidine compound and a process for preparing the same | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2006-06-22 | — | — | US | disclosed |
| US-7045625-B2 | Asymmetric process for the preparation of diarylethylpiperazines derivatives and novel asymmetric diarylmethylamines as intermediates | ASTRAZENECA AB (SE) | 2006-05-16 | — | — | US | disclosed |
| US-20060074238-A1 | Asymmetric process for the preparation of diarylethylpiperazines derivatives and novel asymmetric diarylmethylamines as intermediates | ASTRAZENECA AB (SE) | 2006-04-06 | — | — | US | disclosed |
| WO-2005105790-A1 | 4- 2- (CYCLOALKYLAMINO) PYRIMIDIN-4-YL ! - (PHENYL) - IMIDAZOLIN-2- ONE DERIVATIVES AS P38 MAP- KINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | TANABE SEIYAKU CO., LTD. (JP) | 2005-11-10 | — | — | WO | disclosed |
| EP-1585481-A2 | PYRAZOLOPYRIMIDINE COMPOUND AND PROCESS FOR PREPARING THE SAME | TANABE SEIYAKU CO., LTD. (JP) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004064721-A2 | A PYRAZOLOPYRIMIDINE COMPOUND AND A PROCESS FOR PREPARING THE SAME | TANABE SEIYAKU CO., LTD. (JP) | 2004-08-05 | — | — | WO | disclosed |
| US-20040077861-A1 | Asymmetric process for the preparation of diarylethylpiperazines derivatives and novel asymmetric diarylmethylamines as intermediates | ASTRAZENECA AB (SE) | 2004-04-22 | — | — | US | disclosed |
| EP-1368325-A1 | NEW ASYMMETRIC PROCESS FOR THE PREPARATION OF DIARYLMETHYLPIPERAZINES DERIVATIVES AND NOVEL ASYMMETRIC DIARYLMETYLAMINES AS INTERMEDIATES | AstraZeneca AB (SE) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002070492-A1 | NEW ASYMMETRIC PROCESS FOR THE PREPARATION OF DIARYLMETHYLPIPERAZINES DERIVATIVES AND NOVEL ASYMMETRIC DIARYLMETYLAMINES AS INTERMEDIATES | ASTRAZENECA AB (SE) | 2002-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060074238-A1 | Asymmetric process for the preparation of diarylethylpiperazines derivatives and novel asymmetric diarylmethylamines as intermediates | SRM, SULT2A1, PNMT | KMT2A 73/4885MEN1 1450/4885CA1 3862/4885 |
| US-20040077861-A1 | Asymmetric process for the preparation of diarylethylpiperazines derivatives and novel asymmetric diarylmethylamines as intermediates | SRM, SULT2A1, PNMT | KMT2A 73/4885MEN1 1450/4885CA1 3862/4885 |
| US-20060135525-A1 | Pyrazolopyrimidine compound and a process for preparing the same | KCNJ2, KCNN2, KCNH2 | KMT2A 638/4885MEN1 2842/4885CA1 3575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.