Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.58 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | PI4KA | P42356 | 1/20 | 0.44 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.44 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.44 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.42 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.42 |
| ▸ | AHCY | P23526 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.41 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744317 | 0.85 | ADORA2A (0.52) | ADORA2AADORA3RXFP1PI4KAPI4K2B | |
| SCHEMBL25408738 | 0.85 | ADORA2A (0.52) | ADORA2AADORA3RXFP1PI4KAPI4K2B | |
| SCHEMBL19692161 | 0.83 | ADORA2A (0.58) | ADORA2AADORA3ADORA1ADORA2BPI4KA | |
| SCHEMBL28156591 | 0.83 | ADORA2A (0.64) | ADORA2AADORA3ADORA1ADORA2BPI4KA | |
| SCHEMBL11040343 | 0.83 | ADORA2A (0.58) | ADORA2AADORA3ADORA1ADORA2BPI4KA | |
| SCHEMBL1078828 | 0.83 | ADORA2A (0.64) | ADORA2AADORA3ADORA1ADORA2BPI4KA | |
| SCHEMBL122975 | 0.83 | ADORA1 (0.62) | ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL8943715 | 0.82 | ADORA2A (0.57) | ADORA2AADORA3ADORA1ADORA2BPI4KA | |
| SCHEMBL5554234 | 0.81 | ADORA2A (0.56) | ADORA2AADORA3ADORA1ADORA2BPI4KA | |
| SCHEMBL9054202 | 0.80 | ADORA2A (0.55) | ADORA2AADORA3ADORA1ADORA2BRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609833-B2 | Purine derivatives as adenosine A1 receptor agonists and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2013-12-17 | — | — | US | disclosed |
| US-20120264706-A1 | PURINE DERIVATIVES AS ADENOSINE A1 RECEPTOR AGONISTS AND METHODS OF USE THEREOF | INOTEK PHARMACEUTICALS CORPORATION (US) | 2012-10-18 | — | — | US | disclosed |
| US-8183224-B2 | Purine derivatives as adenosine A1 receptor agonists and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2012-05-22 | — | — | US | disclosed |
| EP-1758596-B9 | PURINE DERIVATIVES AS ADENOSINE A1 RECEPTOR AGONISTS AND METHODS OF USE THEREOF | INOTEK PHARMACEUTICALS CORP (US) | 2010-09-15 | — | — | EP | disclosed |
| EP-2221307-A1 | Purine derivatives as adenosine A1 receptor agonists and methods of use thereof | Inotek Pharmaceuticals Corporation (US) | 2010-08-25 | — | — | EP | disclosed |
| EP-1758596-B1 | PURINE DERIVATIVES AS ADENOSINE A1 RECEPTOR AGONISTS AND METHODS OF USE THEREOF | INOTEK PHARMACEUTICALS CORP (US) | 2010-03-31 | — | — | EP | disclosed |
| US-20090062314-A1 | Purine derivatives as adenosine A1 receptor agonists and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2009-03-05 | — | — | US | disclosed |
| US-7423144-B2 | Purine Derivatives as adenosine A1 receptor agonists and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2008-09-09 | — | — | US | disclosed |
| EP-1758596-A4 | PURINE DERIVATIVES AS ADENOSINE A1 RECEPTOR AGONISTS AND METHODS OF USE THEREOF | INOTEK PHARMACEUTICALS CORP (US) | 2007-08-01 | — | — | EP | disclosed |
| EP-1758596-A2 | PURINE DERIVATIVES AS ADENOSINE A1 RECEPTOR AGONISTS AND METHODS OF USE THEREOF | Inotek Pharmaceuticals Corporation (US) | 2007-03-07 | — | — | EP | disclosed |
| US-20050282768-A1 | Purine derivatives as adenosine A1 receptor agonists and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION | 2005-12-22 | — | — | US | disclosed |
| WO-2005117910-A2 | PURINE DERIVATIVES AS ADENOSINE A1 RECEPTOR AGONISTS AND METHODS OF USE THEREOF | INOTEK PHARMACEUTICALS CORPORATION (US) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282768-A1 | Purine derivatives as adenosine A1 receptor agonists and methods of use thereof | ADORA2A, ADORA1, ADORA3 | ADORA2A 1/4885ADORA3 3/4885ADORA1 2/4885 |
| US-20090062314-A1 | Purine derivatives as adenosine A1 receptor agonists and methods of use thereof | ADORA2A, ADORA1, ADORA3 | ADORA2A 1/4885ADORA3 3/4885ADORA1 2/4885 |
| US-20120264706-A1 | PURINE DERIVATIVES AS ADENOSINE A1 RECEPTOR AGONISTS AND METHODS OF USE THEREOF | ADORA2A, ADORA1, ADORA3 | ADORA2A 1/4885ADORA3 3/4885ADORA1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.