SCHEMBL28215006

SCHEMBL28215006

N#Cc1cccc(CO)c1C#N

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 1/20 0.40
ALDH1A1 P00352 4/20 0.39
MAPT P10636 2/20 0.39
KDM4E B2RXH2 1/20 0.39
MEN1 O00255 1/20 0.39
GAA P10253 1/20 0.39
CACNA1B Q00975 1/20 0.39
APBA1 Q02410 1/20 0.39
KMT2A Q03164 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.38
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
ESR2 Q92731 1/20 0.37
HIF1A Q16665 1/20 0.37
MAOA P21397 1/20 0.36
MAOB P27338 1/20 0.36
TSHR P16473 4/20 0.35
HSD11B1 P28845 1/20 0.35
CYP19A1 P11511 1/20 0.35
APOBEC3G Q9HC16 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16952962 0.87 S1PR1 (0.47) S1PR1ALDH1A1MAPTKDM4EMEN1
SCHEMBL16950896 0.86 S1PR1 (0.37) S1PR1ALDH1A1MAPTKDM4EMEN1
SCHEMBL2096195 0.81 KDM4E (0.35) S1PR1ALDH1A1MAPTKDM4EMEN1
SCHEMBL483697 0.80 ALDH1A1 (0.49) ALDH1A1MAPTKMT2ASMN1; SMN2CA1
SCHEMBL30496165 0.80 ALDH1A1 (0.49) ALDH1A1MAPTKMT2ASMN1; SMN2CA1
SCHEMBL6958245 0.79 CA1 (0.37) ALDH1A1MAPTSMN1; SMN2CA1CA2
SCHEMBL27756124 0.79 SMN1; SMN2 (0.37) ALDH1A1MAPTKDM4ESMN1; SMN2CA1
SCHEMBL11524213 0.79 GABRA1 (0.41) SMN1; SMN2CA1CA2HIF1AMAOA
SCHEMBL1378624 0.79 CA1 (0.41) ALDH1A1MAPTKDM4EGAASMN1; SMN2
SCHEMBL1125092 0.79 SMN1; SMN2 (0.37) ALDH1A1MAPTKDM4ESMN1; SMN2CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106068254-B The manufacturing method and manufacture device of dicyanobenzenes 三菱瓦斯化学株式会社 2018-05-18 CN disclosed