Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Tetrahydrofolate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOST | Q9BQB4 | 1/20 | 0.95 |
| ▸ | FPGS | Q05932 | 2/20 | 0.85 |
| ▸ | GART | P22102 | 5/20 | 0.72 |
| ▸ | DHFR | P00374 | 1/20 | 0.65 |
| ▸ | ATIC | P31939 | 3/20 | 0.63 |
| ▸ | MTHFD1 | P11586 | 2/20 | 0.60 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofolate SCHEMBL1069545 | 0.98 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL4535491 | 0.98 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL29435894 | 0.98 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL9879710 | 0.98 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL8030 | 0.98 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL30051444 | 0.98 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL2691812 | 0.98 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL29870853 | 0.98 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL159231 | 0.98 | SOST (1.00) | SOSTFPGSGARTDHFRATIC | |
| Tetrahydrofolate SCHEMBL258530 | 0.98 | SOST (1.00) | SOSTFPGSGARTDHFRATIC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108033962-B | A method of synthesis (6S) -5-methyltetrahydrofolate salt | 连云港金康和信药业有限公司 | 2019-08-30 | — | — | CN | disclosed |
| CN-108033962-A | The method of one kind synthesis (6S) -5-methyltetrahydrofolate salt | 连云港金康和信药业有限公司 | 2018-05-15 | — | — | CN | disclosed |