Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 1/20 | 0.62 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.52 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.52 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.52 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12096453 | 0.88 | L3MBTL1 (0.68) | KCNK3KCNK9KMT2AMEN1L3MBTL1 | |
| SCHEMBL7785693 | 0.86 | MAPT (0.63) | KCNK3KCNK9KMT2AMEN1L3MBTL1 | |
| SCHEMBL17950520 | 0.81 | ATM (0.75) | KCNK3KCNK9KMT2AMEN1L3MBTL1 | |
| SCHEMBL14392191 | 0.81 | MAPK13 (0.66) | KCNK3KCNK9KMT2AMEN1L3MBTL1 | |
| SCHEMBL209624 | 0.80 | ATM (0.67) | KCNK3KCNK9KMT2AMEN1L3MBTL1 | |
| SCHEMBL22529980 | 0.78 | PTPN1 (0.66) | KMT2AMEN1L3MBTL1RAB9ANPC1 | |
| SCHEMBL2512416 | 0.78 | ATM (0.63) | KCNK3KCNK9KMT2AMEN1L3MBTL1 | |
| SCHEMBL1814173 | 0.77 | KCNK3 (0.82) | KCNK3KCNK9KMT2AMEN1L3MBTL1 | |
| SCHEMBL20491276 | 0.77 | SMN1; SMN2 (0.63) | KCNK3KCNK9KMT2AMEN1GAA | |
| SCHEMBL23932088 | 0.77 | KMT2A (0.66) | KCNK3KCNK9KMT2AMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108069976-A | A kind of nitrogenous macrocyclic compounds, its preparation method, pharmaceutical composition and application | 山东罗欣药业集团股份有限公司 | 2018-05-25 | — | — | CN | disclosed |