Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | BRD2 | P25440 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826202 | 0.87 | BRD4 (0.47) | BRD4BRD2CREBBPUCHL1CA12 | |
| SCHEMBL2823123 | 0.83 | BRD4 (0.41) | BRD4BRD2CREBBPUCHL1CA12 | |
| SCHEMBL17823712 | 0.83 | P2RX3 (0.38) | HIF1AF2P2RX3P2RX2 | |
| SCHEMBL16237809 | 0.82 | UCHL1 (0.49) | BRD4BRD2CREBBPUCHL1CA12 | |
| SCHEMBL14746472 | 0.82 | CA12 (0.49) | UCHL1CA12CA1CA2CA7 | |
| SCHEMBL2822082 | 0.80 | ALDH1A1 (0.42) | BRD4BRD2CREBBPUCHL1CA12 | |
| SCHEMBL13291141 | 0.80 | BRD4 (0.41) | BRD4BRD2CREBBPCA12CA1 | |
| SCHEMBL2825580 | 0.79 | UCHL1 (0.40) | BRD4BRD2CREBBPUCHL1CA12 | |
| SCHEMBL17823765 | 0.79 | GRM5 (0.41) | P2RX3P2RX2 | |
| SCHEMBL17832666 | 0.79 | GRM5 (0.41) | P2RX3P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069504-A1 | (3-OXO)PYRIDIN-4-YLUREA DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL, S.A. (ES) | 2010-06-24 | — | — | WO | disclosed |
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |