Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.37 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11434090 | 0.86 | XDH (0.43) | MEN1KMT2AABCC9ABCC8KCNJ11 | |
| SCHEMBL5479625 | 0.81 | NPC1 (0.49) | — | |
| SCHEMBL7409664 | 0.77 | PRKCI (0.40) | KDRKCNH2CASP1MEN1KMT2A | |
| SCHEMBL2977013 | 0.77 | HSD17B10 (0.42) | KDRMEN1KMT2APARP1PARP10 | |
| SCHEMBL22067721 | 0.77 | MAPK8 (0.39) | KDRMEN1KMT2AMAPK8PARP1 | |
| SCHEMBL12663273 | 0.76 | CYP2A6 (0.45) | KDRHRH4MEN1KMT2AABCC9 | |
| SCHEMBL14291553 | 0.76 | CYP2A6 (0.45) | KDRHRH4MEN1KMT2AABCC9 | |
| SCHEMBL5483765 | 0.76 | DGAT1 (0.51) | KDRCASP1MEN1KMT2APARP1 | |
| SCHEMBL28252825 | 0.76 | FLT1 (0.56) | KDRCASP1MEN1KMT2AADRA1D | |
| SCHEMBL28222517 | 0.76 | LMNA (0.46) | MEN1KMT2AMAPK8PARP1PARP15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105399685-B | The alternatively preparation method and applications of the heteroaromatic compounds of property JAK3 and/or JAK1 kinase inhibitors | 深圳微芯生物科技有限责任公司 | 2018-05-22 | — | — | CN | disclosed |