SCHEMBL28225645

SCHEMBL28225645

CC(C)COOC(=O)C(C)c1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.47
TSHR P16473 2/20 0.47
GPR88 Q9GZN0 1/20 0.44
CYP1A2 P05177 1/20 0.42
CYP2D6 P10635 1/20 0.42
PKM P14618 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
PTGS2 P35354 6/20 0.42
PTGS1 P23219 6/20 0.42
KMT2A Q03164 1/20 0.42
HPGD P15428 1/20 0.39
PGR P06401 1/20 0.39
ADORA3 P0DMS8 1/20 0.39
SLC6A2 P23975 1/20 0.39
P2RX4 Q99571 1/20 0.39
LMNA P02545 2/20 0.39
CYP2C9 P11712 2/20 0.39
AKR1C3 P42330 2/20 0.39
CXCR1 P25024 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2296619 0.84 ALDH1A1 (0.56) ALDH1A1TSHRGPR88CYP1A2CYP2D6
SCHEMBL11650568 0.84 ALDH1A1 (0.56) ALDH1A1TSHRGPR88CYP1A2CYP2D6
SCHEMBL7651108 0.83 KMT2A (0.52) CYP2D6PTGS2PTGS1KMT2ALMNA
SCHEMBL4635157 0.81 KMT2A (0.44) ALDH1A1TSHRGPR88CYP1A2CYP2D6
SCHEMBL3804982 0.81 ALDH1A1 (0.49) ALDH1A1TSHRPTGS2PTGS1KMT2A
SCHEMBL26698292 0.80 TSHR (0.45) ALDH1A1TSHRGPR88CYP1A2CYP2D6
SCHEMBL15201697 0.80 KMT2A (0.53) GPR88CYP2D6PTGS2PTGS1KMT2A
SCHEMBL10853683 0.79 ALDH1A1 (0.51) ALDH1A1TSHRGPR88CYP1A2CYP2D6
SCHEMBL27643864 0.79 GPR88 (0.49) ALDH1A1TSHRGPR88SMN1; SMN2NPSR1
SCHEMBL13168121 0.77 PTGS1 (0.47) ALDH1A1TSHRGPR88CYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108250087-A A kind of synthetic method of 4- isobutoxies benzylamine 常州大学 2018-07-06 CN disclosed