Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | PDE8A | O60658 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | PDE9A | O76083 | 1/20 | 0.31 |
| ▸ | PDE6A | P16499 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26975105 | 0.78 | SLC2A1 (0.32) | SLC2A1ALDH1A1MAPTKMT2A | |
| SCHEMBL16680007 | 0.77 | MAPK1 (0.36) | LMNAAPPBACE1BACE2MAPK1 | |
| Oxindole SCHEMBL28860972 | 0.77 | AHR (0.45) | APPBACE1BACE2MAPK1MAPKAPK2 | |
| SCHEMBL14720969 | 0.76 | APP (0.43) | APPBACE1BACE2MAPK1MAPKAPK2 | |
| SCHEMBL7940962 | 0.75 | TSHR (0.40) | LMNAAPPBACE1BACE2KDM4E | |
| SCHEMBL14720728 | 0.74 | APP (0.45) | APPBACE1BACE2MAPK1KDM4E | |
| SCHEMBL16679299 | 0.72 | MEN1 (0.36) | LMNAMAPK1TLR7ALDH1A1KMT2A | |
| SCHEMBL16755476 | 0.70 | NOS1 (0.38) | MAPKAPK2 | |
| SCHEMBL4265783 | 0.70 | CHRNB2 (0.33) | PDE2APDE8APDE5APDE9APDE6A | |
| SCHEMBL28052421 | 0.68 | MAPKAPK2 (0.38) | APPBACE1BACE2MAPK1MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137561-A | Indolin-2-one derivative | 豪夫迈·罗氏有限公司 | 2018-06-08 | — | — | CN | disclosed |