Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 6/20 | 0.36 |
| ▸ | PLK1 | P53350 | 3/20 | 0.36 |
| ▸ | INSR | P06213 | 2/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.34 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28225950 | 0.77 | LMNA (0.39) | MAPKAPK2APPBACE1BACE2MAPK1 | |
| Oxindole SCHEMBL11087237 | 0.67 | AHR (0.78) | AHRPDK2SRCGRIA1CACNG8 | |
| Oxindole SCHEMBL2832789 | 0.67 | AHR (0.91) | AHRPDK2SRCGRIA1CACNG8 | |
| Oxindole SCHEMBL1144643 | 0.67 | AHR (1.00) | AHRPDK2SRCGRIA1CACNG8 | |
| Oxindole SCHEMBL29358826 | 0.67 | AHR (1.00) | AHRPDK2SRCGRIA1CACNG8 | |
| Oxindole SCHEMBL19504 | 0.67 | AHR (1.00) | AHRPDK2SRCGRIA1CACNG8 | |
| Oxindole SCHEMBL15636313 | 0.65 | AHR (0.95) | AHRPDK2SRCGRIA1CACNG8 | |
| Oxindole SCHEMBL1462135 | 0.65 | AHR (0.95) | AHRPDK2SRCGRIA1CACNG8 | |
| Oxindole SCHEMBL4720301 | 0.65 | AHR (0.95) | AHRPDK2SRCGRIA1CACNG8 | |
| Oxindole SCHEMBL5668060 | 0.65 | AHR (0.95) | AHRPDK2SRCGRIA1CACNG8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137561-A | Indolin-2-one derivative | 豪夫迈·罗氏有限公司 | 2018-06-08 | — | — | CN | disclosed |