Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.52 |
| ▸ | SYK | P43405 | 2/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.52 |
| ▸ | PLK4 | O00444 | 3/20 | 0.51 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ACP1 | P24666 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28753755 | 0.86 | ABCG2 (0.55) | JAK2SYKABCG2ALDH1A1CYP1A2 | |
| SCHEMBL20357748 | 0.86 | JAK2 (0.56) | JAK2SYKABCG2PLK4PLK1 | |
| SCHEMBL20529569 | 0.83 | PLK4 (0.72) | JAK2ABCG2PLK4AURKAAURKB | |
| SCHEMBL28941887 | 0.83 | NPC1 (0.59) | SYKABCG2PLK4PLK1ALDH1A1 | |
| SCHEMBL28753785 | 0.79 | SYK (0.61) | JAK2SYKABCG2ALDH1A1LMNA | |
| SCHEMBL28227359 | 0.79 | ROCK2 (0.61) | JAK2SYKABCG2PLK4ALDH1A1 | |
| SCHEMBL23906681 | 0.76 | JAK2 (0.52) | JAK2SYKPLK4PLK1AURKA | |
| SCHEMBL30086676 | 0.76 | JAK2 (0.52) | JAK2SYKPLK4PLK1AURKA | |
| SCHEMBL2422608 | 0.75 | ABCG2 (0.72) | ABCG2ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL31098951 | 0.74 | FLT3 (0.65) | JAK2SYKPLK4ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108707151-A | Pyrimido-pyridazinone compound and application thereof | 阿萨纳生物科技有限责任公司 | 2018-10-26 | — | — | CN | claimed |
| CN-103974955-B | Pyrimido-pyridazinone compounds and uses thereof | 阿萨纳生物科技有限责任公司 | 2018-06-19 | — | — | CN | claimed |
| CN-103974955-A | Pyrimido-pyridazinone compounds and uses thereof | ENDO PHARMACEUTICALS INC | 2014-08-06 | — | — | CN | claimed |
| CN-108707151-A | Pyrimido-pyridazinone compound and application thereof | 阿萨纳生物科技有限责任公司 | 2018-10-26 | — | — | CN | disclosed |