Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24878447 | 0.87 | MET (0.38) | METAXLBRD4CSNK1DCSNK1E | |
| SCHEMBL28199991 | 0.82 | BRD4 (0.35) | METAXLBRD4CSNK1DCSNK1E | |
| SCHEMBL28200012 | 0.81 | BRD4 (0.32) | METBRD4 | |
| SCHEMBL11554969 | 0.77 | BRD4 (0.43) | METAXLBRD4PTGS2MAPT | |
| SCHEMBL20351762 | 0.77 | BRD4 (0.39) | METAXLBRD4CSNK1DCSNK1E | |
| SCHEMBL28199937 | 0.74 | NR4A2 (0.33) | METBRD4MAPT | |
| SCHEMBL22200868 | 0.73 | ALDH1A1 (0.40) | METAXLBRD4CSNK1DCSNK1E | |
| SCHEMBL26084053 | 0.73 | MET (0.37) | METAXLBRD4CSNK1DCSNK1E | |
| SCHEMBL28200609 | 0.73 | NFATC1 (0.40) | CSNK1DCSNK1EMAPK13MAPK12MAPK11 | |
| SCHEMBL2591376 | 0.72 | MET (0.48) | METAXLLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108250200-A | A kind of compound and its preparation and application with Axl inhibitory activity | 中国科学院上海药物研究所 | 2018-07-06 | — | — | CN | disclosed |