Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MET | P08581 | 2/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21769348 | 0.80 | CDC25A (0.39) | ALDH1A1KDM4EPOLBKMT2AMET | |
| SCHEMBL11554969 | 0.78 | BRD4 (0.43) | METAXLBRD4PTGS1PTGS2 | |
| SCHEMBL20351762 | 0.78 | BRD4 (0.39) | ALDH1A1KDM4EMETAXLBRD4 | |
| SCHEMBL24878447 | 0.75 | MET (0.38) | ALDH1A1KDM4EKMT2AMETAXL | |
| SCHEMBL26084053 | 0.74 | MET (0.37) | METAXLBRD4PTGS1MAPK13 | |
| SCHEMBL20003671 | 0.73 | PTGS1 (0.37) | ALDH1A1KDM4EPOLBKMT2ABRD4 | |
| SCHEMBL28229642 | 0.73 | MET (0.36) | POLBMETAXLBRD4PTGS1 | |
| SCHEMBL2591376 | 0.73 | MET (0.48) | ALDH1A1KDM4EKMT2AMETAXL | |
| SCHEMBL18861192 | 0.72 | AXL (0.45) | KMT2AMETAXLPTGS1PTGS2 | |
| SCHEMBL18031351 | 0.72 | ALDH1A1 (0.33) | ALDH1A1POLBKMT2APTGS1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020141470-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES | ARRAY BIOPHARMA INC. (US) | 2020-07-09 | — | — | WO | disclosed |