Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27932529 | 0.67 | POLB (0.32) | POLB | |
| SCHEMBL17233963 | 0.65 | — | — | |
| SCHEMBL1423865 | 0.65 | — | — | |
| SCHEMBL6887988 | 0.64 | KMT2A (0.36) | POLBKMT2A | |
| SCHEMBL28099160 | 0.63 | POLB (0.44) | POLBSMN1; SMN2KMT2A | |
| SCHEMBL4789264 | 0.63 | CA1 (0.31) | POLB | |
| SCHEMBL7319404 | 0.63 | KMT2A (0.52) | POLBSMN1; SMN2KMT2A | |
| SCHEMBL1965970 | 0.61 | POLB (1.00) | POLBSMN1; SMN2KMT2A | |
| SCHEMBL2284447 | 0.61 | POLB (0.48) | POLBSMN1; SMN2 | |
| SCHEMBL16001319 | 0.60 | LMNA (0.44) | POLBSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109939113-A | Bicyclic bromine structural domain inhibitor | 齐尼思表观遗传学有限公司 | 2019-06-28 | — | — | CN | disclosed |
| CN-105407888-B | Novel bicyclic bromodomain inhibitors | 齐尼思表观遗传学有限公司 | 2019-05-21 | — | — | CN | disclosed |
| CN-108290843-A | Biaryl based kinase inhibitors | 百时美施贵宝公司 | 2018-07-17 | — | — | CN | disclosed |