Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CDC25B | P30305 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | TERT | O14746 | 1/20 | 0.33 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7627710 | 0.88 | POLB (0.35) | POLBADORA3NPSR1MEN1KMT2A | |
| SCHEMBL1191487 | 0.86 | MEN1 (0.40) | POLBADORA3NPSR1MEN1KMT2A | |
| SCHEMBL28086933 | 0.72 | CHEK1 (0.33) | POLBADORA3NPSR1ALOX15 | |
| SCHEMBL30452391 | 0.72 | CYP3A4 (0.36) | POLBADORA3NPSR1MEN1KMT2A | |
| SCHEMBL28113418 | 0.69 | CA12 (0.38) | POLBADORA3NPSR1NPC1KDM4E | |
| SCHEMBL27749294 | 0.68 | BCHE (0.37) | RAB9ABCHES100A4ALDH1A1TSHR | |
| SCHEMBL17906986 | 0.68 | PRKDC (0.42) | POLBMEN1KMT2ACDC25BSMN1; SMN2 | |
| SCHEMBL9055973 | 0.68 | SIGMAR1 (0.39) | POLBMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL18284673 | 0.68 | CYP19A1 (0.39) | POLBADORA3NPSR1CA12CA1 | |
| SCHEMBL642226 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107652289-A | Substituted tricyclic compound as FGFR inhibitor | 因塞特控股公司 | 2018-02-02 | — | — | CN | claimed |
| CN-107383009-A | Substituted tricyclic compound as FGFR inhibitor | 因塞特控股公司 | 2017-11-24 | — | — | CN | claimed |
| CN-110128480-A | organic electroluminescent material and device | 环球展览公司 | 2019-08-16 | — | — | CN | disclosed |
| CN-106061480-A | Therapeutic inhibitory compounds | 莱福斯希医药公司 | 2016-10-26 | — | — | CN | disclosed |
| CN-105992768-A | Imidazopyridazine compounds useful as modulators of il-12, il-23 and/or ifn alpha responses | 百时美施贵宝公司 | 2016-10-05 | — | — | CN | disclosed |
| CN-104395309-B | Cyclic bridgehead ether DGAT1 inhibitors | 诺华股份有限公司 | 2016-09-28 | — | — | CN | disclosed |