Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ODC1 | P11926 | 2/20 | 0.37 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.35 |
| ▸ | FDPS | P14324 | 2/20 | 0.35 |
| ▸ | ARG1 | P05089 | 1/20 | 0.35 |
| ▸ | ARG2 | P78540 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10659088 | 1.00 | ODC1 (0.37) | ODC1NAALAD2CYP2D6NFKB1BLM | |
| SCHEMBL7924611 | 0.84 | ODC1 (0.37) | ODC1NAALAD2CYP2D6NFKB1BLM | |
| SCHEMBL6567609 | 0.84 | ODC1 (0.37) | ODC1NAALAD2CYP2D6NFKB1BLM | |
| SCHEMBL30410707 | 0.81 | NAALAD2 (0.47) | ODC1NAALAD2CYP2D6NFKB1BLM | |
| SCHEMBL10912285 | 0.78 | ODC1 (0.42) | ODC1NAALAD2CYP2D6NFKB1BLM | |
| SCHEMBL27905222 | 0.76 | ODC1 (0.46) | ODC1NAALAD2CYP2D6NFKB1BLM | |
| Hydrochloric Acid SCHEMBL2543241 | 0.75 | NAALAD2 (0.39) | ODC1NAALAD2CYP2D6NFKB1BLM | |
| SCHEMBL28937251 | 0.75 | NAALAD2 (0.39) | NAALAD2KMT2AMEN1TDP1 | |
| SCHEMBL7963542 | 0.75 | NAALAD2 (0.39) | NAALAD2KMT2AMEN1TDP1 | |
| SCHEMBL625789 | 0.74 | FDPS (0.33) | ODC1NAALAD2FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200188476-A1 | ANTI-MICROBIAL AGENT-POLYMER CONJUGATES AND METHODS OF USE THEREOF | UNIV CALIFORNIA (US) | 2020-06-18 | — | — | US | disclosed |
| WO-2018195078-A1 | ANTI-MICROBIAL AGENT-POLYMER CONJUGATES AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-10-25 | — | — | WO | disclosed |
| EP-3263586-A1 | SHORT FATTY ACID TAIL POLYMYXIN DERIVATIVES AND USES THEREOF | Northern Antibiotics Oy (FI) | 2018-01-03 | — | — | EP | disclosed |
| EP-3078672-A1 | POLYMYXIN DERIVATIVES AND USES THEREOF | Northern Antibiotics Oy (FI) | 2016-10-12 | — | — | EP | disclosed |
| EP-2057185-B1 | POLYMYXIN DERIVATIVES AND USES THEREOF | NORTHERN ANTIBIOTICS OY (FI) | 2016-05-11 | — | — | EP | disclosed |
| US-9096649-B2 | Polymyxin derivatives and uses thereof | NORTHERN ANTIBIOTICS LTD. (FI) | 2015-08-04 | — | — | US | disclosed |
| US-9090669-B2 | Short fatty acid tail polymyxin derivatives and uses thereof | NORTHERN ANTIBIOTICS LTD. (FI) | 2015-07-28 | — | — | US | disclosed |
| US-9067974-B2 | Polymyxin derivatives and uses thereof | NORTHERN ANTIBIOTICS OY (FI) | 2015-06-30 | — | — | US | disclosed |
| US-20140162937-A1 | POLYMYXIN DERIVATIVES AND USES THEREOF | NORTHERN ANTIBIOTICS LTD. (FI) | 2014-06-12 | — | — | US | disclosed |
| US-20140142030-A1 | SHORT FATTY ACID TAIL POLYMYXIN DERIVATIVES AND USES THEREOF | NORTHERN ANTIBIOTICS LTD. (FI) | 2014-05-22 | — | — | US | disclosed |
| US-7807637-B2 | Polymyxin derivatives and uses thereof | NORTHERN ANTIBIOTICS OY (FI) | 2010-10-05 | — | — | US | disclosed |
| US-20090239792-A1 | SHORT FATTY ACID TAIL POLYMYXIN DERIVATIVES AND USES THEREOF | NORTHERN ANTIBIOTICS LTD. (FI) | 2009-09-24 | — | — | US | disclosed |
| US-20090215677-A1 | POLYMYXIN DERIVATIVES AND USES THEREOF | NORTHERN ANTIBIOTICS LTD. (FI) | 2009-08-27 | — | — | US | disclosed |
| WO-2009098357-A1 | SHORT FATTY ACID TAIL POLYMYXIN DERIVATIVES AND USES THEREOF | NORTHERN ANTIBIOTICS OY (FI) | 2009-08-13 | — | — | WO | disclosed |
| EP-2057185-A1 | POLYMYXIN DERIVATIVES AND USES THEREOF | Northern Antibiotics Oy (FI) | 2009-05-13 | — | — | EP | disclosed |
| US-20080287345-A1 | Polymyxin derivatives and uses thereof | NORTHERN ANTIBIOTICS OY (FI) | 2008-11-20 | — | — | US | disclosed |
| WO-2008017734-A1 | POLYMYXIN DERIVATIVES AND USES THEREOF | NORTHERN ANTIBIOTICS OY (FI) | 2008-02-14 | — | — | WO | disclosed |
| EP-0169300-B1 | PROCESS FOR PREPARATION OF ALPHA-ALKYL AMINO ACIDS | MERCK & CO. INC. (US) | 1988-05-25 | — | — | EP | disclosed |
| EP-0169300-A1 | Process for preparation of alpha-alkyl amino acids | MERCK & CO. INC. (US) | 1986-01-29 | — | — | EP | disclosed |
| US-4508921-A | Process for preparation of alpha-alkyl amino acids | MERCK & CO., INC. (US) | 1985-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239792-A1 | SHORT FATTY ACID TAIL POLYMYXIN DERIVATIVES AND USES THEREOF | TLR5, TLR3, TLR2 | ODC1 3795/4885NAALAD2 302/4885CYP2D6 3495/4885 |
| US-20090215677-A1 | POLYMYXIN DERIVATIVES AND USES THEREOF | C5, C9, C3AR1 | ODC1 708/4885NAALAD2 892/4885CYP2D6 2822/4885 |
| US-20140162937-A1 | POLYMYXIN DERIVATIVES AND USES THEREOF | SLC11A2, TLR2, TLR5 | ODC1 1543/4885NAALAD2 529/4885CYP2D6 1874/4885 |
| US-20200188476-A1 | ANTI-MICROBIAL AGENT-POLYMER CONJUGATES AND METHODS OF USE THEREOF | DDOST, MGAM, MSN | ODC1 3120/4885NAALAD2 285/4885CYP2D6 4142/4885 |
| US-20140142030-A1 | SHORT FATTY ACID TAIL POLYMYXIN DERIVATIVES AND USES THEREOF | VIP, ELOVL5, TLR5 | ODC1 4032/4885NAALAD2 460/4885CYP2D6 3551/4885 |
| US-20080287345-A1 | Polymyxin derivatives and uses thereof | C9, C5, C3AR1 | ODC1 674/4885NAALAD2 893/4885CYP2D6 2718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.