Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HK1 | P19367 | 1/20 | 0.46 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SNCA | P37840 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1861037 | 0.83 | IDO1 (0.53) | IDO1METAP2IKBKBMAPTHPGD | |
| SCHEMBL7312649 | 0.83 | MAPT (0.51) | MAPTRAB9AALDH1A1PDE2APDE3B | |
| SCHEMBL1392639 | 0.82 | ADORA3 (0.56) | MAPTRAB9AALDH1A1PDE2APDE3B | |
| SCHEMBL11245286 | 0.76 | CYP1A2 (0.63) | METAP2ALDH1A1PDE2APDE3BPDE3A | |
| SCHEMBL2829502 | 0.76 | CYP1A2 (0.62) | IDO1METAP2IKBKBMAPTHPGD | |
| Bromide SCHEMBL11742008 | 0.74 | CYP1A2 (0.61) | IDO1METAP2IKBKBMAPTHPGD | |
| SCHEMBL16500506 | 0.74 | SNCA (0.60) | IDO1METAP2IKBKBMAPTHPGD | |
| SCHEMBL2851298 | 0.74 | SCN9A (0.54) | IDO1METAP2MAPTHPGDRAB9A | |
| SCHEMBL16115554 | 0.73 | NPC1 (0.66) | IDO1METAP2IKBKBMAPTHPGD | |
| SCHEMBL11242864 | 0.73 | PDE3B (0.61) | IDO1MAPTHPGDALDH1A1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069504-A1 | (3-OXO)PYRIDIN-4-YLUREA DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL, S.A. (ES) | 2010-06-24 | — | — | WO | disclosed |
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |