Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 3/20 | 0.46 |
| ▸ | CTSS | P25774 | 3/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | PPIA | P62937 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10151699 | 0.95 | CTSB (0.46) | CTSBCTSSCTSLCHRM1MEN1 | |
| SCHEMBL1305698 | 0.92 | CHRM1 (0.50) | CTSBCTSSCTSLCHRM1MEN1 | |
| SCHEMBL18038887 | 0.91 | CTSL (0.46) | CTSBCTSSCTSLMEN1KMT2A | |
| SCHEMBL2826325 | 0.88 | CTSL (0.46) | CTSBCTSSCTSLALDH1A1GAA | |
| SCHEMBL9952383 | 0.86 | CTSB (0.44) | CTSBCTSSCTSLALDH1A1GAA | |
| SCHEMBL24421577 | 0.86 | TSHR (0.45) | CTSBCTSSCTSLALDH1A1GAA | |
| SCHEMBL9951765 | 0.84 | CTSS (0.46) | CTSBCTSSCTSLALDH1A1GAA | |
| SCHEMBL1305844 | 0.82 | CTSL (0.48) | CTSBCTSSCTSLALDH1A1GAA | |
| SCHEMBL17141146 | 0.82 | CTSL (0.51) | CTSBCTSSCTSLALDH1A1GAA | |
| SCHEMBL1308680 | 0.82 | CTSL (0.46) | CTSBCTSSCTSLMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858833-B9 | AMINONORBORNANE DERIVATIVE AND MANUFACTURE METHOD THEREOF AND USE THEREOF | TRANSTHERA SCIENCES NANJING INC (CN) | 2026-03-11 | — | — | EP | disclosed |
| EP-3858833-B1 | AMINONORBORNANE DERIVATIVE AND MANUFACTURE METHOD THEREOF AND USE THEREOF | TRANSTHERA SCIENCES NANJING INC (CN) | 2025-10-22 | — | — | EP | disclosed |
| US-20250179023-A1 | HOLOSYMMETRIC BIPHENYL DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | ABBISKO THERAPEUTICS CO., LTD. (CN) | 2025-06-05 | — | — | US | disclosed |
| US-12291534-B2 | Aminonorbornane derivative and manufacture method therefor and use thereof | TRANSTHERA SCIENCES (NANJING), INC. (CN) | 2025-05-06 | — | — | US | disclosed |
| US-12202831-B2 | Small molecule inhibitors of the JAK family of kinases | JANSSEN PHARMACEUTICA NV (BE) | 2025-01-21 | — | — | US | disclosed |
| EP-4491617-A1 | HOLOSYMMETRIC BIPHENYL DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2025-01-15 | — | — | EP | disclosed |
| US-12030885-B2 | Substituted imidazo[2,1-f][1,2,4]triazines as PI3K-gamma inhibitors | INCYTE CORPORATION (US) | 2024-07-09 | — | — | US | disclosed |
| US-11827638-B2 | Imidazopyrrolopyridine as inhibitors of the JAK family of kinases | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-28 | — | — | US | disclosed |
| US-11787807-B2 | Small molecule inhibitors of the JAK family of kinases | JANSSEN PHARMACEUTICA NV (BE) | 2023-10-17 | — | — | US | disclosed |
| WO-2023169373-A1 | HOLOSYMMETRIC BIPHENYL DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海和誉生物医药科技有限公司 | 2023-09-14 | — | — | WO | disclosed |
| WO-2018112382-A1 | IMIDAZOPYRROLOPYRIDINE AS INHIBITORS OF THE JAK FAMILY OF KINASES | JANSSEN PHARMACEUTICA NV (BE) | 2018-06-21 | — | — | WO | disclosed |
| WO-2018112379-A1 | SMALL MOLECULE INHIBITORS OF THE JAK FAMILY OF KINASES | JANSSEN PHARMACEUTICA NV (BE) | 2018-06-21 | — | — | WO | disclosed |
| US-20180170931-A1 | Small Molecule Inhibitors of the JAK Family of Kinases | JANSSEN PHARMACEUTICA NV (BE) | 2018-06-21 | — | — | US | disclosed |
| US-20180009816-A1 | HETEROCYCLIC COMPOUNDS AS PI3K-y INHIBITORS | INCYTE CORPORATION | 2018-01-11 | — | — | US | disclosed |
| US-20180009816-A1 | HETEROCYCLIC COMPOUNDS AS PI3K-y INHIBITORS | INCYTE CORPORATION | 2018-01-11 | — | — | US | disclosed |
| WO-2017223414-A1 | HETEROCYCLIC COMPOUNDS AS PI3K-γ INHIBITORS | INCYTE CORPORATION (US) | 2017-12-28 | — | — | WO | disclosed |
| US-8507493-B2 | Amide and amidine derivatives and uses thereof | ABBVIE INC. (US) | 2013-08-13 | — | — | US | disclosed |
| WO-2010123838-A2 | NOVEL AMIDE AND AMIDINE DERIVATIVES AND USES THEREOF | ABBOTT LABORATORIES (US) | 2010-10-28 | — | — | WO | disclosed |
| EP-2243479-A2 | Novel amide and amidine derivates and uses thereof | Abbott Laboratories (US) | 2010-10-27 | — | — | EP | disclosed |
| US-20100267738-A1 | NOVEL AMIDE AND AMIDINE DERIVATIVES AND USES THEREOF | ABBOTT LABORATORIES (US) | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11787807-B2 | Small molecule inhibitors of the JAK family of kinases | JAK2, JAK1, JAK3 | CTSB 2784/4885CTSS 2845/4885CTSL 3170/4885 |
| US-11827638-B2 | Imidazopyrrolopyridine as inhibitors of the JAK family of kinases | JAK1, JAK2, JAK3 | CTSB 3944/4885CTSS 4143/4885CTSL 3536/4885 |
| US-20100267738-A1 | NOVEL AMIDE AND AMIDINE DERIVATIVES AND USES THEREOF | HSD11B2, HSD11B1, HSD17B2 | CTSB 3670/4885CTSS 3289/4885CTSL 4342/4885 |
| US-12030885-B2 | Substituted imidazo[2,1-f][1,2,4]triazines as PI3K-gamma inhibitors | PIK3CG, PIK3CD, PIK3R5 | CTSB 4527/4885CTSS 4404/4885CTSL 4794/4885 |
| US-12291534-B2 | Aminonorbornane derivative and manufacture method therefor and use thereof | BTK, LCK, SYK | CTSB 3408/4885CTSS 1757/4885CTSL 2572/4885 |
| US-20180009816-A1 | HETEROCYCLIC COMPOUNDS AS PI3K-y INHIBITORS | PIK3R5, PIK3CA, PIK3CD | CTSB 3160/4885CTSS 3748/4885CTSL 4830/4885 |
| US-20250179023-A1 | HOLOSYMMETRIC BIPHENYL DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | CD274, PDCD1, PDCD1LG2 | CTSB 1882/4885CTSS 1735/4885CTSL 1051/4885 |
| US-12202831-B2 | Small molecule inhibitors of the JAK family of kinases | JAK1, JAK2, JAK3 | CTSB 2932/4885CTSS 2870/4885CTSL 3291/4885 |
| US-20180170931-A1 | Small Molecule Inhibitors of the JAK Family of Kinases | JAK1, JAK2, JAK3 | CTSB 2932/4885CTSS 2870/4885CTSL 3291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.