Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.50 |
| ▸ | KIF11 | P52732 | 3/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | TLR2 | O60603 | 1/20 | 0.44 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9658757 | 0.85 | KIF11 (0.46) | LRRK2KIF11CCR2PTGS2PDK1 | |
| Hydrochloric Acid SCHEMBL6511708 | 0.83 | ALDH1A1 (0.47) | LRRK2KIF11CCR2PTGS2PDK1 | |
| SCHEMBL23143944 | 0.81 | PDK1 (0.48) | LRRK2KIF11CCR2PDK1PDK2 | |
| SCHEMBL23143977 | 0.79 | LRRK2 (0.42) | LRRK2KIF11CCR2PTGS2PDK1 | |
| SCHEMBL13436030 | 0.77 | LRRK2 (0.40) | LRRK2TLR2TLR1PTGS2PDK1 | |
| SCHEMBL14242830 | 0.77 | KIF11 (0.51) | KIF11CCR2PTGS2HRH4 | |
| SCHEMBL14875298 | 0.77 | CA1 (0.49) | LRRK2KIF11TLR2TLR1PTGS2 | |
| SCHEMBL585873 | 0.77 | KIF11 (0.60) | KIF11CCR2PTGS2HRH4 | |
| SCHEMBL23155765 | 0.76 | LRRK2 (0.46) | LRRK2TLR2TLR1PTGS2PDK1 | |
| SCHEMBL23155477 | 0.75 | LMNA (0.48) | LRRK2KIF11CCR2PDK1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108484595-B | Simple synthesis method of asthma medicine Fevipiprant | 天津科技大学 | 2021-03-30 | — | — | CN | claimed |
| CN-108137503-B | Process for the preparation of 1- (4-methanesulfonyl-2-trifluoromethyl-benzyl) -2-methyl-1H-pyrrolo [2,3-B ] pyridin-3-yl-acetic acid | 诺华股份有限公司 | 2021-06-15 | — | — | CN | disclosed |
| CN-108484595-B | Simple synthesis method of asthma medicine Fevipiprant | 天津科技大学 | 2021-03-30 | — | — | CN | disclosed |
| CN-110461840-A | The method for preparing 1- (4- mesyl -2- romethyl-benzy) -2- methyl-1 H- pyrrolo- [2,3-b] pyridin-3-yl-acetic acid | NOVARTIS AG | 2019-11-15 | — | — | CN | disclosed |
| CN-108484595-A | A kind of succinct synthetic method of asthmatic medicament Fevipiprant | 天津科技大学 | 2018-09-04 | — | — | CN | disclosed |