Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.73 |
| ▸ | TRPA1 | O75762 | 16/20 | 0.71 |
| ▸ | METAP2 | P50579 | 2/20 | 0.58 |
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.57 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12683720 | 0.84 | AXL (1.00) | AXLTRPA1METAP2TRPM8TRPV1 | |
| SCHEMBL28198038 | 0.78 | METAP2 (0.64) | AXLTRPA1METAP2 | |
| SCHEMBL28237558 | 0.76 | METAP2 (0.66) | AXLTRPA1METAP2TRPV1 | |
| SCHEMBL21514162 | 0.76 | METAP2 (0.66) | AXLTRPA1METAP2TRPV1 | |
| SCHEMBL12315709 | 0.75 | METAP2 (0.64) | AXLTRPA1METAP2 | |
| SCHEMBL14784319 | 0.74 | METAP2 (1.00) | AXLMETAP2 | |
| SCHEMBL30120562 | 0.73 | TRPA1 (1.00) | TRPA1TRPM8TRPV1 | |
| SCHEMBL197671 | 0.72 | HSD11B1 (0.56) | TRPA1TRPM8TRPV1 | |
| SCHEMBL20267944 | 0.71 | TRPA1 (1.00) | TRPA1TRPM8TRPV1 | |
| SCHEMBL28133423 | 0.71 | TRPA1 (0.79) | TRPA1TRPM8TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105683194-B | The inhibitor of (azepine) pyrido PyrazolopyrimidinonecGMP and indazole hepyramine as fibrinolysis | 拜耳制药股份公司 | 2018-09-14 | — | — | CN | disclosed |