SCHEMBL282399

SCHEMBL282399

Nc1ccc(O)cc1C(F)(F)F

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 7/20 0.53
KIF11 P52732 2/20 0.42
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA7 P43166 1/20 0.41
CA9 Q16790 1/20 0.41
CA14 Q9ULX7 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
HSD17B3 P37058 1/20 0.41
NR1I2 O75469 1/20 0.40
ALDH1A1 P00352 1/20 0.40
LMNA P02545 1/20 0.40
CYP2C9 P11712 1/20 0.40
MIF P14174 1/20 0.40
TYR P14679 1/20 0.40
ALOX15 P16050 1/20 0.40
HTT P42858 1/20 0.40
NFE2L2 Q16236 1/20 0.40
HSD17B10 Q99714 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29396798 1.00 FFAR4 (0.53) FFAR4KIF11CA12CA1CA2
SCHEMBL5513401 0.82 KIF11 (0.47) FFAR4KIF11CA12CA1CA2
SCHEMBL30368360 0.78 KIF11 (0.52) KIF11HSD17B3NR1I2ALDH1A1LMNA
SCHEMBL3022860 0.78 KIF11 (0.52) KIF11HSD17B3NR1I2ALDH1A1LMNA
SCHEMBL5383436 0.77 ALDH1A1 (0.61) FFAR4CA12CA1CA2CA7
SCHEMBL349356 0.76 KIF11 (0.50) FFAR4KIF11ALDH1A1ALOX15HSD17B10
SCHEMBL29402330 0.76 GAA (0.67) FFAR4KIF11SMN1; SMN2ALDH1A1HSD17B10
SCHEMBL30595362 0.76 ALDH1A1 (0.60) KIF11CA12CA1CA2CA7
SCHEMBL31256038 0.76 GLA (0.54) KIF11HSD17B3NR1I2ALDH1A1LMNA
SCHEMBL29403371 0.76 KIF11 (0.50) FFAR4KIF11ALDH1A1ALOX15HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 202 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117247515-A Polyimide containing Trringer's Base element and gas separation membrane and method prepared by polyimide 西北工业大学 2023-12-19 CN claimed
CN-116854913-A Preparation method of high-impact-resistance bismaleimide resin 西北工业大学 2023-10-10 CN claimed
CN-116854679-A Novel epoxy resin containing imide unit and preparation method thereof 西北工业大学 2023-10-10 CN claimed
CN-116178689-A Liquid crystal polymer and preparation method and application thereof 深圳大学 2023-05-30 CN claimed
CN-111303426-B Polyimide film and method for preparing polyimide film by click chemistry 西北工业大学 2022-07-05 CN claimed
CN-110229158-B Thermosetting polyimide precursor with low melt viscosity and suitable for RTM (resin transfer molding) and preparation method thereof 西北工业大学 2022-06-07 CN claimed
CN-110218287-B High-performance self-repairing polyimide based on dynamic imine bond and preparation method thereof 西北工业大学 2022-03-15 CN claimed
CN-109824894-B Preparation method of polyimide film with molecular main chain alternately composed of two acid anhydrides 西北工业大学 2021-08-10 CN claimed
CN-111303426-A Polyimide film and method for preparing polyimide film by click chemistry 西北工业大学 2020-06-19 CN claimed
CN-110229158-A Low melt viscosity is suitable for the molding Thermocurable polyimide presoma of RTM and preparation method 西北工业大学 2019-09-13 CN claimed
CN-101253169-A Substituted benzimidazoles and processes for their preparation NOVARTIS AG (CH) 2008-08-27 CN claimed
CN-101253168-A Substituted benzimidazoles as kinase inhibitors NOVARTIS AG (CH) 2008-08-27 CN claimed
US-20080139795-A1 Preparation of halogenated 4-aminophenols LANXESS DEUTSCHLAND GMBH (DE) 2008-06-12 US claimed
CN-101058639-A Fluorine-containing polyimide basal body resin and preparation method thereof CHINESE ACAD INST CHEMISTRY (CN) 2007-10-24 CN claimed
US-20050143425-A1 Preparation of halogenated 4-aminophenols LANXESS DEUTSCHLAND GMBH (DE) 2005-06-30 US claimed
CN-1616412-A Process for the preparation of halogen containing 4-amino phenols BAYER CHEMICALS AG (DE) 2005-05-18 CN claimed
EP-1514865-A1 Process for the preparation of halogen containing 4-amino phenols Bayer Chemicals AG (DE) 2005-03-16 EP claimed
EP-0299497-B1 Dye composition for keratinous fiber KAO CORP (JP) 1994-02-16 EP claimed
US-4871372-A AS DEVELOPER A TRIFLUOROMETHYLATED P-PHENYLENEDIAMINE KAO CORPORATION (JP) 1989-10-03 US claimed
EP-0299497-A2 Dye composition for keratinous fiber Kao Corporation (JP) 1989-01-18 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080139795-A1 Preparation of halogenated 4-aminophenols CYP4X1, CYP4B1, PAH FFAR4 341/4885KIF11 2867/4885CA12 3912/4885
US-20050143425-A1 Preparation of halogenated 4-aminophenols CYP4X1, HPD, CYP4F8 FFAR4 336/4885KIF11 3177/4885CA12 3747/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.