Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 4/20 | 0.53 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mannitol SCHEMBL28135357 | 0.87 | TRPM8 (0.70) | TRPM8TRPA1EPHX1LMNA | |
| Mannitol SCHEMBL9859912 | 0.87 | TRPM8 (0.70) | TRPM8TRPA1EPHX1LMNA | |
| Menthol SCHEMBL18690327 | 0.84 | TRPM8 (0.70) | TRPM8TRPA1EPHX1LMNATRPV1 | |
| Demannose SCHEMBL28209682 | 0.81 | TRPM8 (0.57) | TRPM8TRPA1EPHX1LMNATRPV1 | |
| Demannose SCHEMBL9474810 | 0.80 | TRPM8 (0.53) | TRPM8TRPA1EPHX1PDE4ATRPV1 | |
| SCHEMBL9648881 | 0.80 | EPHX1 (0.49) | TRPM8TRPA1EPHX1PDE4ALMNA | |
| SCHEMBL11689709 | 0.79 | EPHX1 (0.38) | TRPM8TRPA1EPHX1PDE4ALMNA | |
| Menthol SCHEMBL583835 | 0.77 | TRPM8 (0.68) | TRPM8TRPA1EPHX1LMNATRPV1 | |
| Levomenthol SCHEMBL2960650 | 0.77 | TRPM8 (0.68) | TRPM8TRPA1EPHX1LMNATRPV1 | |
| SCHEMBL9617783 | 0.77 | EPHX1 (0.45) | EPHX1LMNACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108525664-A | A kind of preparation and its application of magnetic Nano nucleocapsid catalyst | 华东师范大学 | 2018-09-14 | — | — | CN | disclosed |