Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 4/20 | 0.68 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.68 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levomenthol SCHEMBL2960650 | 1.00 | TRPM8 (0.68) | TRPM8TRPA1EPHX1CYP19A1ALDH1A1 | |
| Menthol SCHEMBL2311281 | 0.93 | TRPM8 (0.78) | TRPM8TRPA1EPHX1CYP19A1ALDH1A1 | |
| Menthol SCHEMBL2634088 | 0.92 | TRPM8 (0.66) | TRPM8TRPA1EPHX1CYP19A1KCNA5 | |
| Menthol SCHEMBL583696 | 0.90 | TRPM8 (0.72) | TRPM8TRPA1EPHX1CYP19A1ALDH1A1 | |
| Levomenthol SCHEMBL2961481 | 0.90 | TRPM8 (0.72) | TRPM8TRPA1EPHX1CYP19A1ALDH1A1 | |
| Menthol SCHEMBL1664554 | 0.90 | TRPM8 (0.84) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| Menthol SCHEMBL15135035 | 0.87 | TRPM8 (0.68) | TRPM8TRPA1EPHX1CYP19A1ALDH1A1 | |
| Menthol SCHEMBL2671170 | 0.87 | TRPM8 (0.72) | TRPM8TRPA1EPHX1CYP19A1ALDH1A1 | |
| Menthol SCHEMBL320045 | 0.85 | TRPM8 (0.75) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| Menthol SCHEMBL1617429 | 0.85 | TRPM8 (0.75) | TRPM8TRPA1EPHX1CYP19A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 644 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110869365-B | Cooling composition | 弗门尼舍有限公司 | 2024-03-29 | — | — | CN | claimed |
| US-20240058243-A1 | A METHOD FOR FIGHTING MICROORGANISMS USING MENTHOL DERIVATIVES | SYMRISE AG (DE) | 2024-02-22 | — | — | US | claimed |
| US-20240000746-A1 | New Cooling Agents and Preparations Containing Them | SYMRISE AG (DE) | 2024-01-04 | — | — | US | claimed |
| EP-4259287-A1 | A METHOD FOR FIGHTING MICROORGANISMS USING MENTHOL DERIVATIVES | Symrise AG (DE) | 2023-10-18 | — | — | EP | claimed |
| EP-4247791-A2 | NEW COOLANTS, AND PREPARATIONS CONTAINING SAME | Symrise AG (DE) | 2023-09-27 | — | — | EP | claimed |
| CN-116583261-A | Method for combating microorganisms using menthol derivatives | 西姆莱斯股份公司 | 2023-08-11 | — | — | CN | claimed |
| WO-2023143741-A1 | NEW COOLANTS, AND PREPARATIONS CONTAINING SAME | SYMRISE AG (DE) | 2023-08-03 | — | — | WO | claimed |
| WO-2023144326-A1 | NEW COOLANTS, AND PREPARATIONS CONTAINING SAME | SYMRISE AG (DE) | 2023-08-03 | — | — | WO | claimed |
| WO-2023117119-A1 | ACTIVE INGREDIENTS WITH SIALAGOGUE AND TINGLING/FIZZY EFFECT, AND PREPARATIONS CONTAINING SAME | SYMRISE AG (DE) | 2023-06-29 | — | — | WO | claimed |
| CN-109640935-B | Mixtures comprising (E) -3-benzo [1,3] dioxol-5-yl-N, N-diphenyl-2-propenamide | 西姆莱斯有限公司 | 2022-10-14 | — | — | CN | claimed |
| US-20060270737-A1 | Menthol propyleneglycol-carbonate and analogs thereof as insect pest repellents | POSEIDON OCEAN SCIENCES | 2006-11-30 | — | — | US | claimed |
| US-20060217456-A1 | Non-toxic coating composition, methods of use thereof and articles protected from attachment of biofouling organisms | SYMRISE GMBH & CO. KG (DE) | 2006-09-28 | — | — | US | claimed |
| EP-1662872-A1 | MENTHOL PROPYLENEGLYCOL-CARBONATE AND ANALOGS THEREOF AS INSECT PEST REPELLENTS. | Poseidon Ocean Sciences (US) | 2006-06-07 | — | — | EP | claimed |
| WO-2006034495-A2 | METHODS OF USING MENTHOL PROPYLENEGLYCOL-CARBONATE AND ANALOGS THEREOF FOR PRODUCING ANTI-INFLAMMATORY AND ANTI-ANGIOGENIC EFFECTS | MATIAS JONATHAN R (US) | 2006-03-30 | — | — | WO | claimed |
| EP-1615974-A1 | NON-TOXIC COATING COMPOSITION, METHODS OF USE THEREOF AND ARTICLES PROTECTED FROM ATTACHMENT OF BIOFOULING ORGANISMS | Symrise GmbH & Co. KG (DE) | 2006-01-18 | — | — | EP | claimed |
| WO-2005025313-A1 | MENTHOL PROPYLENEGLYCOL-CARBONATE AND ANALOGS THEREOF AS INSECT PEST REPELLENTS. | POSEIDON OCEAN SCIENCES (US) | 2005-03-24 | — | — | WO | claimed |
| WO-2004090052-A1 | NON-TOXIC COATING COMPOSITION, METHODS OF USE THEREOF AND ARTICLES PROTECTED FROM ATTACHMENT OF BIOFOULING ORGANISMS | SYMRISE GMBH & CO. KG (DE) | 2004-10-21 | — | — | WO | claimed |
| EP-1466949-A1 | Non-toxic coating composition, methods of use thereof and articles protected from attachment of biofouling organisms | Symrise GmbH & Co. KG (DE) | 2004-10-13 | — | — | EP | claimed |
| EP-1461057-A1 | A TOPICAL ANTI-ITCH FORMULATION AND A PROCESS FOR THE PREPARATION THEREOF | Johnson & Johnson Limited (IN) | 2004-09-29 | — | — | EP | claimed |
| WO-2003047609-A1 | A TOPICAL ANTI-ITCH FORMULATION AND A PROCESS FOR THE PREPARATION THEREOF | JOHNSON & JOHNSON LIMITED (IN) | 2003-06-12 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240058243-A1 | A METHOD FOR FIGHTING MICROORGANISMS USING MENTHOL DERIVATIVES | MGLL, GCDH, GK | TRPM8 84/4885TRPA1 187/4885EPHX1 1246/4885 |
| US-20060270737-A1 | Menthol propyleneglycol-carbonate and analogs thereof as insect pest repellents | MLEC, GLMN, MGLL | TRPM8 49/4885TRPA1 368/4885EPHX1 2162/4885 |
| US-20240000746-A1 | New Cooling Agents and Preparations Containing Them | TTPA, TREH, TAS2R45 | TRPM8 132/4885TRPA1 313/4885EPHX1 1993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.