Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Levomenthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 4/20 | 0.68 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.68 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Menthol SCHEMBL583835 | 1.00 | TRPM8 (0.68) | TRPM8TRPA1EPHX1CYP19A1ALDH1A1 | |
| Menthol SCHEMBL2311281 | 0.93 | TRPM8 (0.78) | TRPM8TRPA1EPHX1CYP19A1ALDH1A1 | |
| Menthol SCHEMBL2634088 | 0.92 | TRPM8 (0.66) | TRPM8TRPA1EPHX1CYP19A1KCNA5 | |
| Menthol SCHEMBL583696 | 0.90 | TRPM8 (0.72) | TRPM8TRPA1EPHX1CYP19A1ALDH1A1 | |
| Levomenthol SCHEMBL2961481 | 0.90 | TRPM8 (0.72) | TRPM8TRPA1EPHX1CYP19A1ALDH1A1 | |
| Menthol SCHEMBL1664554 | 0.90 | TRPM8 (0.84) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| Menthol SCHEMBL15135035 | 0.87 | TRPM8 (0.68) | TRPM8TRPA1EPHX1CYP19A1ALDH1A1 | |
| Menthol SCHEMBL2671170 | 0.87 | TRPM8 (0.72) | TRPM8TRPA1EPHX1CYP19A1ALDH1A1 | |
| Menthol SCHEMBL320045 | 0.85 | TRPM8 (0.75) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| Menthol SCHEMBL1617429 | 0.85 | TRPM8 (0.75) | TRPM8TRPA1EPHX1CYP19A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110558408-A | Aerated herbal tea beverage and preparation method thereof | 成都图径生物科技有限公司 | 2019-12-13 | — | — | CN | claimed |
| CN-114380693-B | Methyl cyclopentenol ketogeraniol carbonate spice and synthetic method and application thereof | 安徽中烟工业有限责任公司 | 2023-11-17 | — | — | CN | disclosed |
| CN-114516797-B | Methyl cyclopentenolone menthol carbonate spice and synthetic method and application thereof | 安徽中烟工业有限责任公司 | 2023-09-08 | — | — | CN | disclosed |
| CN-114516797-A | Methyl cyclopentenolone menthol carbonate spice as well as synthesis method and application thereof | 安徽中烟工业有限责任公司 | 2022-05-20 | — | — | CN | disclosed |
| CN-114380693-A | Methyl cyclopentenolone geraniol carbonate spice and synthesis method and application thereof | 安徽中烟工业有限责任公司 | 2022-04-22 | — | — | CN | disclosed |
| CN-111517958-B | Perilla alcohol benzyl alcohol carbonate spice | 北京工商大学 | 2022-01-25 | — | — | CN | disclosed |
| CN-111440071-B | Perilla alcohol cinnamyl alcohol carbonate spice | 北京工商大学 | 2022-01-25 | — | — | CN | disclosed |
| CN-111517958-A | Perilla alcohol benzyl alcohol carbonate spice | 北京工商大学 | 2020-08-11 | — | — | CN | disclosed |
| CN-111440071-A | Perilla alcohol cinnamyl alcohol carbonate spice | 北京工商大学 | 2020-07-24 | — | — | CN | disclosed |
| CN-110558408-A | Aerated herbal tea beverage and preparation method thereof | 成都图径生物科技有限公司 | 2019-12-13 | — | — | CN | disclosed |
| EP-2187871-B1 | MIXTURES COMPRISING PELLITORIN AND USES THEREOF | SYMRISE AG (DE) | 2016-04-13 | — | — | EP | disclosed |
| US-20100273887-A1 | MIXTURES COMPRISING PELLITORIN AND USES THEREOF | SYMRISE GMBH & CO. KG (DE) | 2010-10-28 | — | — | US | disclosed |
| EP-2187871-A1 | MIXTURES COMPRISING PELLITORIN AND USES THEREOF | Symrise GmbH & Co. KG (DE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009021558-A1 | MIXTURES COMPRISING PELLITORIN AND USES THEREOF | SYMRISE GMBH & CO. KG (DE) | 2009-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273887-A1 | MIXTURES COMPRISING PELLITORIN AND USES THEREOF | NISCH, TAS2R40, TAS2R60 | TRPM8 55/4885TRPA1 230/4885EPHX1 3306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.