Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 10/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1948836 | 0.80 | PGR (0.47) | PGRALDH1A1MEN1KMT2ACYP2D6 | |
| SCHEMBL30372076 | 0.73 | HRH3 (0.51) | PGRALDH1A1MEN1KMT2ACASP3 | |
| SCHEMBL26452862 | 0.72 | CASP3 (0.41) | PGRALDH1A1MEN1KMT2ACYP2D6 | |
| SCHEMBL22787107 | 0.72 | PGR (0.44) | PGRALDH1A1MDM2KDM4EMAPT | |
| SCHEMBL3941349 | 0.72 | ALDH1A1 (0.41) | PGRALDH1A1MEN1KMT2ACYP2D6 | |
| SCHEMBL30620824 | 0.70 | HRH3 (0.52) | PGRALDH1A1MEN1KMT2ACASP3 | |
| SCHEMBL13136409 | 0.70 | MDM2 (0.44) | PGRALDH1A1MEN1KMT2ACYP2D6 | |
| SCHEMBL30564277 | 0.70 | HRH3 (0.52) | PGRALDH1A1MEN1KMT2ACASP3 | |
| SCHEMBL5453638 | 0.69 | PGR (0.62) | PGRALDH1A1MEN1KMT2ACYP2D6 | |
| SCHEMBL3665606 | 0.69 | HRH3 (0.40) | PGRALDH1A1MEN1KMT2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108602805-A | Isoindoline, azaisoindoline, indenone and the dihydro azepine indone inhibitor of MNK1 and MNK2 | 效应治疗股份有限公司 | 2018-09-28 | — | — | CN | disclosed |