Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 2/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 2/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2825609 | 0.92 | SMN1; SMN2 (0.44) | DHODHADORA2AADORA1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2824252 | 0.91 | FABP3 (0.38) | DHODHTNKSTNKS2PARP2ADORA2A | |
| SCHEMBL2826082 | 0.90 | ENPP1 (0.43) | ENPP1TNKSTNKS2PARP2ADORA2A | |
| SCHEMBL2824206 | 0.89 | DHODH (0.37) | DHODHADORA2AADORA1ALDH1A1L3MBTL1 | |
| SCHEMBL2825639 | 0.89 | NR1H2 (0.40) | PTGDR2 | |
| SCHEMBL2826114 | 0.87 | CYP1A2 (0.39) | DHODHTNKSTNKS2PARP2ALDH1A1 | |
| SCHEMBL2821965 | 0.85 | FABP3 (0.39) | ADORA2AADORA1SMN1; SMN2PTGDR2KMT2A | |
| SCHEMBL2829123 | 0.84 | ENPP1 (0.40) | ENPP1DHODHTNKSTNKS2PARP2 | |
| SCHEMBL2824267 | 0.82 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL2824685 | 0.81 | KDM4E (0.41) | DHODHTNKSTNKS2PARP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809605-B1 | QUINOLINES AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | claimed |