Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | VNN1 | O95497 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | P4HB | P07237 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL646582 | 0.85 | KMT2A (0.49) | ALDH1A1ALOX15TRPA1MAP2K1P4HB | |
| SCHEMBL30361968 | 0.83 | MAP2K1 (0.51) | GRM5VNN1TRPA1MAP2K1P4HB | |
| SCHEMBL284291 | 0.83 | MAP2K1 (0.51) | GRM5VNN1TRPA1MAP2K1P4HB | |
| SCHEMBL29726442 | 0.81 | CASP1 (0.44) | ALDH1A1GRM5VNN1TRPA1MAP2K1 | |
| SCHEMBL923754 | 0.81 | CASP1 (0.44) | ALDH1A1GRM5VNN1TRPA1MAP2K1 | |
| SCHEMBL7213897 | 0.81 | GRM5 (0.46) | ALDH1A1GRM5VNN1TRPA1MAP2K1 | |
| SCHEMBL1692766 | 0.81 | GRM5 (0.49) | ALDH1A1GRM5VNN1TRPA1MAP2K1 | |
| SCHEMBL21056017 | 0.79 | VCAM1 (0.47) | ALDH1A1HTTLMNAMAPTTSHR | |
| Hydrochloric Acid SCHEMBL15190391 | 0.79 | CA1 (0.47) | ALDH1A1GRM5VNN1TRPA1MAP2K1 | |
| SCHEMBL7951890 | 0.78 | TTR (0.39) | ALDH1A1MAP2K1MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025098515-A1 | HETEROCYCLIC DERIVATIVES, COMPOSITIONS AND USES THEREOF | DANATLAS PHARMACEUTICALS CO., LTD. (CN) | 2025-05-15 | — | — | WO | disclosed |
| WO-2025082533-A1 | FUSED-RING COMPOUNDS, PREPARATION THEREFOR AND USE THEREOF | 上海轶诺药业有限公司 | 2025-04-24 | — | — | WO | disclosed |
| WO-2024028169-A1 | NOVEL SPECIFICALLY SUBSTITUTED THIOPHENOLIC COMPOUNDS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2024-02-08 | — | — | WO | disclosed |
| CN-111630030-B | Novel benzamide derivatives as PPAR-gamma modulators | 梅迪比奥法尔玛公司 | 2023-06-20 | — | — | CN | disclosed |
| US-11267808-B2 | Benzamide derivatives as PPAR-gamma modulators | MEDIBIOFARMA, S.L. (ES) | 2022-03-08 | — | — | US | disclosed |
| EP-3724165-B1 | NEW BENZAMIDE DERIVATIVES AS PPAR-GAMMA MODULATORS | MEDIBIOFARMA S L (ES) | 2022-01-12 | — | — | EP | disclosed |
| EP-3724165-B1 | NEW BENZAMIDE DERIVATIVES AS PPAR-GAMMA MODULATORS | MEDIBIOFARMA S L (ES) | 2022-01-12 | — | — | EP | disclosed |
| US-20210171511-A1 | NEW BENZAMIDE DERIVATIVES AS PPAR-GAMMA MODULATORS | MEDIBIOFARMA, S.L. (ES) | 2021-06-10 | — | — | US | disclosed |
| US-20210171511-A1 | NEW BENZAMIDE DERIVATIVES AS PPAR-GAMMA MODULATORS | MEDIBIOFARMA, S.L. (ES) | 2021-06-10 | — | — | US | disclosed |
| EP-3724165-A1 | NEW BENZAMIDE DERIVATIVES AS PPAR-GAMMA MODULATORS | MEDIBIOFARMA, S.L. (ES) | 2020-10-21 | — | — | EP | disclosed |
| US-20030092677-A1 | Glutamate receptor antagonists | ADAM GEO (DE) | 2003-05-15 | — | — | US | disclosed |
| US-20030055085-A1 | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists | ASTRAZENECA AB (SE) | 2003-03-20 | — | — | US | disclosed |
| US-6509328-B1 | Metabotropic glutamate receptor antagonists and accordingly are useful for the treatment of a range of neurological disorders, including psychosis, schizophrenia, Alzheimer's and others | HOFFMANN-LA ROCHE INC. | 2003-01-21 | — | — | US | disclosed |
| WO-2002068417-A3 | HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | SLASSI ABDELMALIK (CA) | 2002-11-14 | — | — | WO | disclosed |
| WO-2002068417-A2 | HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | NPS PHARMACEUTICALS, INC. (US) | 2002-09-06 | — | — | WO | disclosed |
| EP-1224175-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| EP-1224174-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| US-6407094-B1 | 4-5-DIDEHYDRO-1,5-BENZODIAZEPIN-2-ONE DERIVATIVES; PSYCHOLOGICAL, NERVOUS SYSTEM, AND BRAIN DISORDERS; COGNITION ACTIVATORS; ALZHEIMER*S DISEASE, SCHIZOPHRENIA | HOFFMANN-LA ROCHE INC. | 2002-06-18 | — | — | US | disclosed |
| WO-2001029012-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |
| WO-2001029011-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210171511-A1 | NEW BENZAMIDE DERIVATIVES AS PPAR-GAMMA MODULATORS | PPARD, PPARG, PPARA | ALDH1A1 597/4885ALOX15 748/4885GRM5 267/4885 |
| US-20030092677-A1 | Glutamate receptor antagonists | GRM1, GRM3, GRM2 | ALDH1A1 637/4885ALOX15 3373/4885GRM5 12/4885 |
| US-11267808-B2 | Benzamide derivatives as PPAR-gamma modulators | PPARG, PPARD, PPARA | ALDH1A1 606/4885ALOX15 783/4885GRM5 270/4885 |
| US-20030055085-A1 | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists | GRM2, GRIN2A, GRM1 | ALDH1A1 3466/4885ALOX15 2672/4885GRM5 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.