Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.33 |
| ▸ | GLS | O94925 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12210066 | 0.81 | ALDH1A1 (0.38) | ALDH1A1BTKHCAR2MEN1KMT2A | |
| SCHEMBL6504302 | 0.77 | ALDH1A1 (0.36) | ALDH1A1BTKMEN1KMT2APOLB | |
| SCHEMBL3529066 | 0.77 | ALDH1A1 (0.49) | ALDH1A1MEN1KMT2ATSHRPOLB | |
| SCHEMBL6496126 | 0.76 | RAB9A (0.39) | ALDH1A1BTKMEN1KMT2AHPGD | |
| SCHEMBL4963424 | 0.73 | ALDH1A1 (0.49) | ALDH1A1MEN1KMT2ATSHRPOLB | |
| SCHEMBL12210064 | 0.73 | RBP4 (0.36) | HCAR2NPC1RAB9A | |
| SCHEMBL7995864 | 0.73 | HCAR2 (0.35) | ALDH1A1BTKHCAR2POLBNPC1 | |
| SCHEMBL21858616 | 0.70 | ALDH1A1 (0.49) | ALDH1A1BTKHCAR2KMT2ATSHR | |
| SCHEMBL27100101 | 0.69 | ALDH1A1 (0.36) | ALDH1A1BTKMEN1KMT2APOLB | |
| SCHEMBL15534756 | 0.69 | COPS5 (0.39) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | disclosed |