Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | RAF1 | P04049 | 3/20 | 0.36 |
| ▸ | BRAF | P15056 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826068 | 0.92 | NPSR1 (0.43) | HPGDTSHRGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL2821184 | 0.91 | SMN1; SMN2 (0.37) | HPGDTSHRALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL2822062 | 0.90 | KDM4E (0.38) | HPGDTSHRALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2825467 | 0.90 | KDM4E (0.38) | HPGDTSHRALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2824314 | 0.85 | ENPP1 (0.35) | HPGDGAAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL2824392 | 0.84 | RAF1 (0.37) | RAF1BRAF | |
| SCHEMBL2828013 | 0.84 | ALDH1A1 (0.36) | ALDH1A1MAPT | |
| SCHEMBL2824028 | 0.83 | FABP3 (0.43) | HPGDGAAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL2825677 | 0.82 | FABP3 (0.45) | HPGDGAAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL2821880 | 0.82 | FABP3 (0.45) | HPGDGAAALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809605-B1 | QUINOLINES AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | claimed |