Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 2/20 | 0.32 |
| ▸ | BRAF | P15056 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 2/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2824392 | 0.93 | RAF1 (0.37) | ENPP1RAF1BRAFHCRTR1HCRTR2 | |
| SCHEMBL2823196 | 0.92 | GAA (0.40) | ENPP1KDM4EMEN1KMT2AHPGD | |
| SCHEMBL2821184 | 0.88 | SMN1; SMN2 (0.37) | ENPP1DHODHKDM4EMEN1HTT | |
| SCHEMBL2822062 | 0.87 | KDM4E (0.38) | ENPP1DHODHKDM4EHTTHPGD | |
| SCHEMBL2825467 | 0.87 | KDM4E (0.38) | ENPP1DHODHKDM4EHTTHPGD | |
| SCHEMBL2824985 | 0.85 | HPGD (0.42) | MEN1KMT2AHPGDRAF1BRAF | |
| SCHEMBL2821290 | 0.85 | DGAT1 (0.38) | MEN1KMT2ARAF1BRAFMAPT | |
| SCHEMBL2825330 | 0.85 | KDM4E (0.41) | KDM4EHPGDALDH1A1 | |
| SCHEMBL2828013 | 0.81 | ALDH1A1 (0.36) | DHODHMAPTALDH1A1 | |
| SCHEMBL2824028 | 0.80 | FABP3 (0.43) | KDM4EMEN1KMT2AHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809605-B1 | QUINOLINES AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | claimed |