Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.36 |
| ▸ | FABP3 | P05413 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2825467 | 0.99 | KDM4E (0.38) | SMN1; SMN2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2822062 | 0.99 | KDM4E (0.38) | SMN1; SMN2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2824028 | 0.92 | FABP3 (0.43) | SMN1; SMN2KDM4EALDH1A1HPGDFABP3 | |
| SCHEMBL2824985 | 0.91 | HPGD (0.42) | SMN1; SMN2ALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL2825677 | 0.91 | FABP3 (0.45) | SMN1; SMN2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2821880 | 0.91 | FABP3 (0.45) | SMN1; SMN2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2829017 | 0.88 | PTGS2 (0.43) | DPP4 | |
| SCHEMBL2824314 | 0.88 | ENPP1 (0.35) | SMN1; SMN2KDM4EALDH1A1HPGDENPP1 | |
| SCHEMBL2821527 | 0.88 | PTGS2 (0.45) | FABP3CYP3A4CYP2D6CYP2C9FABP4 | |
| SCHEMBL2824392 | 0.87 | RAF1 (0.37) | ENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809605-B1 | QUINOLINES AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | claimed |