SCHEMBL28250334

SCHEMBL28250334

C#C[C@@H](OCCO)c1cccc(C#N)c1

nearest known ligand 0.37

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 2/20 0.37
HSD11B1 P28845 1/20 0.36
S1PR1 P21453 2/20 0.36
TNF P01375 1/20 0.36
GRM4 Q14833 1/20 0.35
FFAR1 O14842 1/20 0.35
ENPP2 Q13822 1/20 0.35
GPR139 Q6DWJ6 1/20 0.34
CNR1 P21554 4/20 0.33
CNR2 P34972 3/20 0.33
FBP1 P09467 2/20 0.33
TACR1 P25103 1/20 0.33
MRGPRX1 Q96LB2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28250339 1.00 GSK3B (0.37) GSK3BHSD11B1S1PR1TNFGRM4
SCHEMBL28250348 0.81 ADRB2 (0.38)
SCHEMBL28250346 0.81 ADRB2 (0.38)
SCHEMBL25207508 0.78 ALDH1A1 (0.39)
SCHEMBL28865641 0.78 ALDH1A1 (0.39)
SCHEMBL195228 0.72 IDO1 (0.37)
SCHEMBL28250328 0.71 SMN1; SMN2 (0.40)
SCHEMBL28250327 0.71 SMN1; SMN2 (0.40)
SCHEMBL11601220 0.70 ENPP2 (0.48) GSK3BS1PR1TNFGRM4ENPP2
SCHEMBL13589661 0.70 S1PR1 (0.41) GSK3BS1PR1TNFGRM4FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108722484-B Composition for preparing propargyl ether 四川大学 2021-04-27 CN disclosed
CN-108722484-A A kind of composition preparing propargyl ether 四川大学 2018-11-02 CN disclosed