Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.59 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 8/20 | 0.56 |
| ▸ | RAB9A | P51151 | 8/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.55 |
| ▸ | RELA | Q04206 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29909885 | 0.85 | IDO1 (0.66) | ADORA1DYRK1ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL758888 | 0.85 | IDO1 (0.66) | ADORA1DYRK1ANPC1RAB9ASMN1; SMN2 | |
| Succinic Acid SCHEMBL28231097 | 0.85 | POLB (0.72) | ADORA1DYRK1ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19974168 | 0.84 | FSCN1 (0.75) | ADORA1DYRK1AFSCN1NPC1RAB9A | |
| SCHEMBL19974167 | 0.84 | FSCN1 (0.75) | ADORA1DYRK1AFSCN1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL3130678 | 0.84 | IDO1 (0.63) | ADORA1DYRK1ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1580942 | 0.76 | NPC1 (0.73) | ADORA1DYRK1AFSCN1NPC1RAB9A | |
| SCHEMBL133638 | 0.75 | ADORA1 (0.71) | ADORA1DYRK1ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8534896 | 0.75 | ADORA1 (0.71) | ADORA1DYRK1ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3283083 | 0.74 | DYRK1A (1.00) | ADORA1DYRK1AFSCN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108799632-A | A kind of high intensity is hinged constant supporting spring hanger | 倍德力能源装备（江苏）有限公司 | 2018-11-13 | — | — | CN | claimed |