Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | PRNP | P04156 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | FABP3 | P05413 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2825632 | 0.90 | ESR1 (0.37) | GAAMAPTNPSR1PRNPPPARG | |
| SCHEMBL2823585 | 0.84 | ALDH1A1 (0.61) | GAAMAPTNPSR1PRNPPPARG | |
| SCHEMBL2821517 | 0.83 | NPSR1 (0.67) | GAAMAPTNPSR1PRNPPPARG | |
| SCHEMBL2823193 | 0.80 | FABP3 (0.45) | GAAMAPTNPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2821493 | 0.80 | MAPT (0.46) | GAAMAPTNPSR1PRNPPPARG | |
| SCHEMBL2821849 | 0.80 | GAA (0.46) | GAAMAPTNPSR1PRNPPPARG | |
| SCHEMBL2823276 | 0.79 | RXFP1 (0.73) | GAAMAPTNPSR1PRNPPPARG | |
| SCHEMBL2824583 | 0.79 | NCF1 (0.43) | GAAMAPTNPSR1RXFP1ALDH1A1 | |
| SCHEMBL2825418 | 0.78 | MAPT (0.44) | GAAMAPTNPSR1PRNPPPARG | |
| SCHEMBL4063767 | 0.75 | ALDH1A1 (0.45) | GAAMAPTNPSR1PRNPPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809605-B1 | QUINOLINES AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | claimed |