Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | PLAUR | Q03405 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2823193 | 0.90 | FABP3 (0.45) | NCF1NPSR1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL2824697 | 0.89 | JAK2 (0.39) | NCF1ALDH1A1SMN1; SMN2MOKLMNA | |
| SCHEMBL2826068 | 0.84 | NPSR1 (0.43) | NCF1NPSR1ALDH1A1KDM4EMC4R | |
| SCHEMBL2821590 | 0.80 | ALDH1A1 (0.52) | NPSR1ALDH1A1KDM4ERXFP1SMN1; SMN2 | |
| SCHEMBL2825469 | 0.79 | GAA (0.45) | NPSR1ALDH1A1KDM4ERXFP1SMN1; SMN2 | |
| SCHEMBL2824985 | 0.77 | HPGD (0.42) | NPSR1ALDH1A1HSD17B10SMN1; SMN2MOK | |
| SCHEMBL2824028 | 0.74 | FABP3 (0.43) | NCF1NPSR1ALDH1A1KDM4ERXFP1 | |
| SCHEMBL2825677 | 0.73 | FABP3 (0.45) | NCF1NPSR1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL2821880 | 0.73 | FABP3 (0.45) | NCF1NPSR1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL2826514 | 0.73 | TACR1 (0.42) | NPSR1SMN1; SMN2GAAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809605-B1 | QUINOLINES AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | claimed |