SCHEMBL2825473

SCHEMBL2825473

O=P(Cl)(Cl)C12CC3CC(CC(C3)C1)C2

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.56
NPSR1 Q6W5P4 1/20 0.39
GRIN2D O15399 4/20 0.35
GRIN3B O60391 4/20 0.35
GRIN1 Q05586 4/20 0.35
GRIN2A Q12879 4/20 0.35
GRIN2B Q13224 4/20 0.35
GRIN2C Q14957 4/20 0.35
GRIN3A Q8TCU5 4/20 0.35
LMNA P02545 2/20 0.35
SLC22A2 O15244 1/20 0.35
SLC22A1 O15245 1/20 0.35
TSHR P16473 1/20 0.35
NFKB1 P19838 1/20 0.35
STAT6 P42226 1/20 0.35
SLC47A1 Q96FL8 1/20 0.35
SIGMAR1 Q99720 1/20 0.35
POLB P06746 1/20 0.33
THRB P10828 1/20 0.33
BLM P54132 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1091418 0.83 GAA (0.56) GAANPSR1GRIN2DGRIN3BGRIN1
SCHEMBL6466244 0.79 GAA (0.65) GAANPSR1GRIN2DGRIN3BGRIN1
SCHEMBL14746227 0.73 GAA (0.41) GAANPSR1LMNATHRBSMN1; SMN2
SCHEMBL5736635 0.72 GAA (1.00) GAANPSR1GRIN2DGRIN3BGRIN1
SCHEMBL1092162 0.72 GAA (0.56) GAANPSR1GRIN2DGRIN3BGRIN1
SCHEMBL27847766 0.72 GAA (0.50) GAANPSR1GRIN2DGRIN3BGRIN1
Hydrochloric Acid SCHEMBL29127785 0.70 GAA (0.68) GAANPSR1GRIN2DGRIN3BGRIN1
Hydrochloric Acid SCHEMBL2825475 0.70 GAA (0.95) GAANPSR1GRIN2DGRIN3BGRIN1
SCHEMBL29144993 0.67 NPSR1 (0.61) GAANPSR1GRIN2DGRIN3BGRIN1
SCHEMBL29361905 0.67 GAA (0.50) GAANPSR1GRIN2DGRIN3BGRIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2243549-B1 A CATALYST SYSTEM LUCITE INT UK LTD (GB) 2020-09-02 EP disclosed
US-9802185-B2 Catalyst system LUCITE INTERNATIONAL UK LIMITED (GB) 2017-10-31 US disclosed
US-20150321186-A1 CATALYST SYSTEM Mitsubishi Chemical UK Limited (GB) 2015-11-12 US disclosed
EP-2243548-B1 A CATALYST SYSTEM LUCITE INT UK LTD (GB) 2015-11-11 EP disclosed
US-9040445-B2 Catalyst system LUCITE INTERNATIONAL UK LIMITED (GB) 2015-05-26 US disclosed
EP-1713582-B1 A CATALYST SYSTEM LUCITE INT UK LTD (GB) 2013-11-06 EP disclosed
EP-1554039-B1 A CATALYST SYSTEM COMPRISING A 1,2-BIS-(PHOSPHINO)METALLOCENE LIGAND LUCITE INT UK LTD (GB) 2013-07-03 EP disclosed
EP-2243549-A1 A catalyst system Lucite International UK Limited (GB) 2010-10-27 EP disclosed
EP-2243548-A1 A catalyst system Lucite International UK Limited (GB) 2010-10-27 EP disclosed
EP-1534427-B1 AN ADAMANTYL CATALYST SYSTEM LUCITE INT UK LTD (GB) 2009-10-21 EP disclosed
US-20060252935-A1 Catalyst system LUCITE INTERNATIONAL UK LIMITED (GB) 2006-11-09 US disclosed
EP-1713582-A1 A CATALYST SYSTEM Lucite International UK Limited (GB) 2006-10-25 EP disclosed
US-20060106259-A1 Phospha-adamantane(s) catalytic system LUCITE INTERNATIONAL UK LIMITED (GB) 2006-05-18 US disclosed
WO-2005079981-A1 A CATALYST SYSTEM LUCITE INTERNATIONAL UK LIMITED (GB) 2005-09-01 WO disclosed
EP-1554039-A2 A CATALYST SYSTEM COMPRISING A 1,2-BIS-(PHOSPHINOALKYL)FERROCENE LIGAND Lucite International UK Limited (GB) 2005-07-20 EP disclosed
EP-1542983-A1 HETERODIAMONDOIDS Chevron U.S.A. Inc. (US) 2005-06-22 EP disclosed
EP-1534427-A1 AN ADAMANTYL CATALYTIC SYSTEM Lucite International UK Limited (GB) 2005-06-01 EP disclosed
WO-2004024322-A2 A CATALYST SYSTEM COMPRISING A 1,2-BIS-(PHOSPHINOALKYL) FERROCENE LIGAND LUCITE INTERNATIONAL UK LIMITED (GB) 2004-03-25 WO disclosed
WO-2004014552-A1 A PHOSPHA-ADAMANTANE (S) CATALYTIC SYSTEM LUCITE INTERNATIONAL UK LIMITED (GB) 2004-02-19 WO disclosed
WO-2004009577-A1 HETERODIAMONDOIDS CHEVRON U.S.A. INC. (US) 2004-01-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060106259-A1 Phospha-adamantane(s) catalytic system ADORA2A, ADORA3, ADGRE5 GAA 3243/4885NPSR1 1370/4885GRIN2D 567/4885
US-20060252935-A1 Catalyst system ELOB, SOD1, ESR1 GAA 1618/4885NPSR1 4525/4885GRIN2D 1910/4885
US-20150321186-A1 CATALYST SYSTEM SMS, COASY, ABCB7 GAA 3561/4885NPSR1 2636/4885GRIN2D 3265/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.