Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 9/20 | 0.55 |
| ▸ | GAA | P10253 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | CHUK | O15111 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | RAD52 | P43351 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11090946 | 0.87 | HPGD (0.55) | HPGDGAALMNAL3MBTL1KDM4E | |
| SCHEMBL28257291 | 0.84 | LOXL2 (0.53) | HPGDLMNAKDM4ETSHRHSD17B10 | |
| SCHEMBL28866282 | 0.82 | ALDH1A1 (0.50) | HPGDGAALMNAKDM4ETSHR | |
| SCHEMBL28257132 | 0.82 | KDM4E (0.51) | HPGDGAALMNAKDM4EHSD17B10 | |
| SCHEMBL28257168 | 0.82 | APP (0.46) | HPGDGAALMNAL3MBTL1TSHR | |
| SCHEMBL28255594 | 0.82 | PDE4A (0.57) | HPGDGAALMNAKDM4ETSHR | |
| SCHEMBL28257164 | 0.80 | APP (0.51) | HPGDGAAL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL28255597 | 0.80 | CYP1A2 (0.52) | HPGDGAALMNAL3MBTL1KDM4E | |
| SCHEMBL26921535 | 0.79 | HPGD (0.47) | HPGDGAALMNAL3MBTL1KDM4E | |
| SCHEMBL28255605 | 0.78 | TSHR (0.63) | HPGDGAALMNAKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108929280-A | Pyrazine derivative and its preparation method and pharmaceutical composition and purposes | 中国医学科学院药物研究所 | 2018-12-04 | — | — | CN | claimed |