Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRB1ADRB2ADRB3CYP11B1DPP4FGFR1FGFR2FGFR3FGFR4HRH1JAK1JAK2JAK3KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITNAOPRD1OPRK1OPRM1PPDGFRBPIK3CDSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASMOTYK2polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Diphenylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.63 |
| ▸ | TSHR | P16473 | 3/20 | 0.63 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.63 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.63 |
| ▸ | HTR2B | P41595 | 1/20 | 0.63 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | AR | P10275 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylamine SCHEMBL27245440 | 1.00 | HSD17B10 (0.67) | HSD17B10ALDH1A1TSHRALOX12TDP1 | |
| Diphenylamine SCHEMBL27245439 | 1.00 | HSD17B10 (0.67) | HSD17B10ALDH1A1TSHRALOX12TDP1 | |
| Diphenylamine SCHEMBL620051 | 0.89 | MAPT (0.64) | HSD17B10ALDH1A1TSHRALOX12TDP1 | |
| Phosphoric Acid SCHEMBL30197486 | 0.87 | MAPT (0.75) | HSD17B10ALDH1A1TSHRALOX12TDP1 | |
| Diphenylamine SCHEMBL10938477 | 0.85 | HSD17B10 (0.55) | HSD17B10ALDH1A1TSHRALOX12TDP1 | |
| Diphenylamine SCHEMBL28255752 | 0.85 | HSD17B10 (0.55) | HSD17B10ALDH1A1TSHRALOX12TDP1 | |
| Diphenylamine SCHEMBL28222060 | 0.85 | HSD17B10 (0.92) | HSD17B10ALDH1A1TSHRALOX12TDP1 | |
| Diphenylamine SCHEMBL28562262 | 0.85 | MAPT (0.59) | HSD17B10ALDH1A1TSHRALOX12TDP1 | |
| SCHEMBL5059514 | 0.84 | CA2 (0.70) | HSD17B10ALDH1A1TSHRALOX12TDP1 | |
| Diphenylamine SCHEMBL29103681 | 0.83 | HSD17B10 (0.67) | HSD17B10ALDH1A1TSHRALOX12TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108912011-A | Light arrangement material | 罗立克科技股份公司 | 2018-11-30 | — | — | CN | disclosed |