Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Diphenylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.64 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | GFER | P55789 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylamine SCHEMBL28562262 | 0.96 | MAPT (0.59) | MAPTALDH1A1CYP3A4L3MBTL1ALOX12 | |
| Phosphoric Acid SCHEMBL30197486 | 0.94 | MAPT (0.75) | MAPTALDH1A1CYP3A4L3MBTL1ALOX12 | |
| Diphenylamine SCHEMBL28255754 | 0.89 | HSD17B10 (0.67) | MAPTALDH1A1CYP3A4L3MBTL1ALOX12 | |
| Diphenylamine SCHEMBL27245439 | 0.89 | HSD17B10 (0.67) | MAPTALDH1A1CYP3A4L3MBTL1ALOX12 | |
| Diphenylamine SCHEMBL27245440 | 0.89 | HSD17B10 (0.67) | MAPTALDH1A1CYP3A4L3MBTL1ALOX12 | |
| Diphenylamine SCHEMBL28576412 | 0.87 | MAPT (0.53) | MAPTALDH1A1CYP3A4L3MBTL1ALOX12 | |
| Aniline SCHEMBL321169 | 0.86 | TSHR (0.65) | CYP3A4TDP1HSD17B10TSHRALOX15 | |
| Diphenylamine SCHEMBL295287 | 0.86 | ALDH1A1 (0.84) | MAPTALDH1A1CYP3A4L3MBTL1ALOX12 | |
| Aniline SCHEMBL675043 | 0.86 | TSHR (0.65) | CYP3A4TDP1HSD17B10TSHRALOX15 | |
| Aniline SCHEMBL5334646 | 0.86 | TSHR (0.65) | CYP3A4TDP1HSD17B10TSHRALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103353505-B | Method for distinguishing DendrobiumofficinaleKimuraetMigo polysaccharides through adopting thin layer chromatography | CROP RES INST GUANGDONG ACADEMY OF AGRICULTURAL SCIENCES | 2015-01-21 | — | — | CN | claimed |
| CN-103353505-A | Method for distinguishing DendrobiumofficinaleKimuraetMigo polysaccharides through adopting thin layer chromatography | CROP RES INST GUANGDONG ACADEMY OF AGRICULTURAL SCIENCES | 2013-10-16 | — | — | CN | claimed |
| CN-101526510-B | Method for rapidly determining content of lactosucrose in food | UNIV NANCHANG | 2012-07-04 | — | — | CN | claimed |
| CN-101625350-B | Method for measuring content of stachyose and raffnose in food | NANCHANG UNIVERSITY (CN) | 2011-12-21 | — | — | CN | claimed |
| CN-101625350-A | Method for measuring content of stachyose and raffnose in food | UNIV NANCHANG | 2010-01-13 | — | — | CN | claimed |
| CN-101526510-A | Method for rapidly determining content of lactosucrose in food | UNIV NANCHANG | 2009-09-09 | — | — | CN | claimed |
| CN-118127100-A | Method for producing sialyllactose by double-bacteria coupling fermentation | 江南大学 | 2024-06-04 | — | — | CN | disclosed |
| CN-113897405-B | Method for synthesizing 3' -sialyllactose by three-strain coupling fermentation at low cost | 江南大学 | 2024-03-01 | — | — | CN | disclosed |
| CN-109679864-B | Strain for producing transglycosylation active beta-galactosidase and method for producing galactooligosaccharide by using same | 石河子大学 | 2023-11-10 | — | — | CN | disclosed |
| EP-4257183-A1 | PREBIOTIC COMPOSITION FOR BUTYRIC ACID BACTERIA | Morinaga Milk Industry Co., Ltd. (JP) | 2023-10-11 | — | — | EP | disclosed |
| CN-115975981-A | Xanthomonas disease-resistant related protein and coding gene and application thereof | 中国农业大学 | 2023-04-18 | — | — | CN | disclosed |
| CN-111206010-B | Recombinant bacillus amyloliquefaciens secreting extracellular alginate lyase and cellulase and application thereof | 杭州丰海生物科技有限公司 | 2022-11-04 | — | — | CN | disclosed |
| CN-113322207-B | Microbacterium XL1 and application thereof in Levan fructan production | 江苏海洋大学 | 2022-05-24 | — | — | CN | disclosed |
| US-5516666-A | TREATING POTASSIUM OR SODIUM ALGINATE WITH ALIGINATE LYASE, DEIONIZING THE PRODUCED OLIGOSACCHARIDE, TREATING THE PRODUCT WITH CALCIUM HYDROXIDE, AND DESALTING AND PURIFYING THE OLIGOSACCHARIDE | MARUHA CORPORATION (JP) | 1996-05-14 | — | — | US | disclosed |
| US-5460957-A | Hypotensive agents | MARUHA CORPORATION (JP) | 1995-10-24 | — | — | US | disclosed |
| US-5378832-A | OF RHAMNOSE, FUCOSE, GLUCOSE AND GLUCURONIC ACID | AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0379999-B1 | Polysaccharide, and water absorbent, moisture absorbent or humectant and thickening agent chiefly made of the polysaccharide, and cultivation method of producing it by a microorganism | HAKUTO CORP (JP) | 1994-12-21 | — | — | EP | disclosed |
| EP-0569591-A1 | POLYSACCHARIDE AND PRODUCTION THEREOF | THE STATE OF JAPAN, as Represented by the DIRECTOR GENERAL of the AGENCY of INDUSTRIAL SCIENCE and TECHNOLOGY (JP) | 1993-11-18 | — | — | EP | disclosed |
| EP-0379999-A1 | Polysaccharide, and water absorbent, moisture absorbent or humectant and thickening agent chiefly made of the polysaccharide, and cultivation method of producing it by a microorganism | HAKUTO CORPORATION (JP) | 1990-08-01 | — | — | EP | disclosed |
| US-3951945-A | Method for the preparation of esters of polyalcohols | B.V. CHEMIE COMBINATIE AMSTERDAM C.C.A. (NL) | 1976-04-20 | — | — | US | disclosed |